, Volume 14, Issue 1, pp 187–195 | Cite as

A Waveguide-Coupled Surface Plasmon Resonance Sensor Using an Au-MgF2-Au Structure

  • Pengfei ZhangEmail author
  • Le Liu
  • Yonghong He
  • Xiaoxia Chen
  • Kaijie Ma
  • Dong Wei


We describe an Au-MgF2-Au trilayered waveguide-coupled surface plasmon resonance (WCSPR) sensor in this article. The characteristics of this sensing structure are compared with those of the conventional single-layered gold surface plasmon resonance (SPR) sensor theoretically and experimentally. The experiment results show that WCSPR can provide not only seven times smaller refractive index resolution in the bulk sensing application but also more accurate measurement results for the biomolecular interaction analysis than the conventional single-layered gold SPR. What’s more, this high-resolution sensor is easy to build and not sensitive to film thickness variations. The Au-MgF2-Au trilayered WCSPR may provide a simple and convenient chip-based strategy for performance enhancement of SPR sensors without varying the hardware and software of measurement instruments.


Surface plasmon resonance Waveguide-coupled surface plasmon resonance Residual analysis Biomolecular interaction analysis 


Funding Information

This research was made possible with the financial support from NSFC China (61275188, 61361160416), Science and Technology Research Program of Shenzhen City (JSGG20150331151536448, CXZZ20140416160720723), and National Key Scientific Instrument and Equipment Development Project (2013YQ040911).


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Beijing Scientific Instrument Research and Development CenterChinese Academy of SciencesBeijingChina
  2. 2.Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and SensingGraduate School at Shenzhen, Tsinghua UniversityShenzhenChina
  3. 3.Institute of Green Chemistry and EnergyGraduate School at Shenzhen, Tsinghua UniversityShenzhenChina
  4. 4.Department of OphthalmologyXin Hua Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghaiChina
  5. 5.Department of PhysicsTsinghua UniversityBeijingChina

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