Science China Technological Sciences

, Volume 62, Issue 4, pp 569–577 | Cite as

A high strength, anti-fouling, self-healable, and thermoplastic supramolecular polymer hydrogel with low fibrotic response

  • HongBo Wang
  • HaoFei Li
  • YuanHao Wu
  • JianHai YangEmail author
  • WenGuang LiuEmail author


The fibrotic response plays an important role in the performance and longevity of implantable devices. Thus, development of effective anti-inflammatory and anti-fibrosis biomaterial implants has become an urgent task. In this work, we developed a novel supramolecular polymer hydrogel through the copolymerization of N-acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) in the absence of any chemical crosslinker, which the mechanical properties being tunable through changing the monomer concentration and the monomer ratio over a broad scope. The hydrogel possessed the superior mechanical performances: high tensile strength (~1.13 MPa), large stretchability (~1200%), and excellent compressive strength (~9 MPa) at high monomer concentration and NAGA/CBAA ratio. Introduction of CBAA could promote the self-healability, thermoplasticity of suparmolecular polymer hydrogels at lower temperatures, meanwhile dramatically improving anti-fouling property. Histological analysis and in vitro cytotoxicity assays testified the excellent biocompatibility of the hydrogel. This high strength supramolecular polymer hydrogel with integrated multiple functions holds promising potentials as a scaffold biomaterial for treating degenerated soft supporting tissues.


supramolecular polymer hydrogel self-healing anti-protein absorption fibrotic response 


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Supplementary material

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjinChina

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