Advertisement

Insight into cellular dedifferentiation in regenerative medicine

  • Tian Hu
  • Bin Yao
  • Sha HuangEmail author
  • Xiaobing FuEmail author
Insight
  • 3 Downloads

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes

Acknowledgements

This study was supported in part by the National Nature Science Foundation of China (81571909, 81701906, 81830064, 81721092), the National Key Research Development Plan (2017YFC1103300), Military Logistics Research Key Project (AWS17J005), and Fostering Funds of Chinese PLA General Hospital for National Distinguished Young Scholar Science Fund (2017-JQPY-002).

References

  1. Alonso-Barroso, E., Brasil, S., Briso-Montiano, Á., Navarrete, R., Pérez-Cerdá, C., Ugarte, M., Pérez, B., Desviat, L.R., and Richard, E. (2017). Generation and characterization of a human iPSC line from a patient with propionic acidemia due to defects in the PCCA gene. Stem Cell Res 23, 173–177.CrossRefGoogle Scholar
  2. Bjornson, C.R.R., Rietze, R.L., Reynolds, B.A., Cristina Magli, M., and Vescovi, A.L. (1999). Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 283, 534–537.CrossRefGoogle Scholar
  3. Duan, L., Liang, Y., Ma, B., Wang, D., Liu, W., Huang, J., Xiong, J., Peng, L., Chen, J., Zhu, W., et al. (2017). DNA methylation profiling in chondrocyte dedifferentiation in vitro. J Cell Physiol 232, 1708–1716.CrossRefGoogle Scholar
  4. Garcia Delgado, A.B., de la Cera, B., Alba Amador, J., Valdes Sanchez, M. L., Fernandez-Munoz, B., Relimpio Lopez, I., Rodriquez de la Rua, E., Diez Lloret, A., Calado, S.M., Sanchez Pernaute, R., et al. (2019). Subretinal transplant of iPSC-derived retinal pigment epithelium on nanostructured fibrin-agarose. Tissue Eng Part A doi:  https://doi.org/10.1089/ten.TEA.2019.0007.
  5. Gurdon, J.B., Elsdale, T.R., and Fischberg, M. (1958). Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature 182, 64–65.CrossRefGoogle Scholar
  6. Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J.V., Gygi, S. P., and Spiegelman, B.M. (2009). Initiation of myoblast to brown fat switch by a PRDM16—C/EBP-β transcriptional complex. Nature 460, 1154–1158.CrossRefGoogle Scholar
  7. Klein, S., Dvornik, J.L., Yarrabothula, A.R., and Schaniel, C. (2017). A Marfan syndrome human induced pluripotent stem cell line with a heterozygous FBN1 c.4082G > A mutation, ISMMSi002-B, for disease modeling. Stem Cell Res 23, 73–76.CrossRefGoogle Scholar
  8. Li, P., Burke, S., Wang, J., Chen, X., Ortiz, M., Lee, S.C., Lu, D., Campos, L., Goulding, D., Ng, B.L., et al. (2010). Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science 329, 85–89.CrossRefGoogle Scholar
  9. Lim, L., and Marin, O. (2018). More than one way to induce a neuron. Nature 557, 316–317.CrossRefGoogle Scholar
  10. Norrmén, C., Figlia, G., Pfistner, P., Pereira, J.A., Bachofner, S., and Suter, U. (2018). mTORC1 is transiently reactivated in injured nerves to promote c-Jun elevation and Schwann cell dedifferentiation. J Neurosci 38, 4811–4828.CrossRefGoogle Scholar
  11. Malta, T.M., Sokolov, A., Gentles, A.J., Burzykowski, T., Poisson, L., Weinstein, J.N., Kamińska, B., Huelsken, J., Omberg, L., Gevaert, O., et al. (2018). Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell 173, 338–354.e15.CrossRefGoogle Scholar
  12. Merrell, A.J., and Stanger, B.Z. (2016). Adult cell plasticity in vivo: dedifferentiation and transdifferentiation are back in style. Nat Rev Mol Cell Biol 17, 413–425.CrossRefGoogle Scholar
  13. Ortuño-Costela, M.D.C., Rodríguez-Mancera, N., García-LöpeZ, M., Zurita-Díaz, F., Moreno-Izquierdo, A., Lucía, A., Martín, M.A., Garesse, R., and Gallardo, M.E. (2017). Establishment of a human iPSC line (IISHDOi001-A) from a patient with McArdle disease. Stem Cell Res 23, 188–192.CrossRefGoogle Scholar
  14. Park, H.T., Kim, J.K., and Tricaud, N. (2019). The conceptual introduction of the “demyelinating Schwann cell” in peripheral demyelinating neuropathies. Glia 67, 571–581.CrossRefGoogle Scholar
  15. Poss, K.D. (2010). Advances in understanding tissue regenerative capacity and mechanisms in animals. Nat Rev Genet 11, 710–722.CrossRefGoogle Scholar
  16. Shah, M., George, R.L., Evancho-Chapman, M.M., and Zhang, G. (2016). Current challenges in dedifferentiated fat cells research. Organogenesis 12, 119–127.CrossRefGoogle Scholar
  17. Sharma, R., Khristov, V., Rising, A., Jha, B.S., Dejene, R., Hotaling, N., Li, Y., Stoddard, J., Stankewicz, C., Wan, Q., et al. (2019). Clinical-grade stem cell—derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs. Sci Transl Med 11, eaat5580.CrossRefGoogle Scholar
  18. Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663–676.CrossRefGoogle Scholar
  19. Vlashi, E., Chen, A.M., Boyrie, S., Yu, G., Nguyen, A., Brower, P.A., Hess, C.B., and Pajonk, F. (2016). Radiation-induced dedifferentiation of head and neck cancer cells into cancer stem cells depends on HPV status. Int J Radiat Oncol Biol Phys 94, 1198–1206.CrossRefGoogle Scholar
  20. Zheng, X., Zhu, Z., Chen, K., Guo, S., Liu, T., and Liu, H. (2017). Establishment of an induced pluripotent stem cell line ZZUi003-A from a 65-year-old male with sporadic Parkinson’s disease. Stem Cell Res 23, 119–121.CrossRefGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Wound Healing and Cell Biology Laboratory, Institute of Basic Medical SciencesGeneral Hospital of PLABeijingChina
  2. 2.Key Laboratory of Tissue Repair and Regeneration of PLA, Beijing Key Research Laboratory of Skin Injury, Repair and Regenerationthe Fourth Medical Center of General Hospital of PLABeijingChina
  3. 3.MRC Human Immunology Unit, MRC Weatherall Institute of Molecular MedicineUniversity of Oxford, John Radcliffe HospitalOxfordUK
  4. 4.The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at ShenzhenTsinghua UniversityShenzhenChina
  5. 5.Tsinghua-Berkeley Shenzhen Institute (TBSI)Tsinghua UniversityShenzhenChina

Personalised recommendations