Advertisement

Science China Life Sciences

, Volume 62, Issue 6, pp 868–869 | Cite as

Investigating loss of heterozygosity in a SCRaMbLEd yeast genome

  • Junbiao DaiEmail author
Research Highlight
  • 42 Downloads

References

  1. Blount, B.A., Gowers, G.O.F., Ho, J.C.H., Ledesma-Amaro, R., Jovicevic, D., McKiernan, R.M., Xie, Z.X., Li, B.Z., Yuan, Y.J., and Ellis, T. (2018). Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome. Nat Commun 9, 1932.CrossRefGoogle Scholar
  2. Deng, G., Lu, Y., Zlotnikov, G., Thor, A.D., and Smith, H.S. (1996). Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274, 2057–2059.CrossRefGoogle Scholar
  3. Hochrein, L., Mitchell, L.A., Schulz, K., Messerschmidt, K., and Mueller-Roeber, B. (2018). L-SCRaMbLE as a tool for light-controlled Cremediated recombination in yeast. Nat Commun 9, 1931.CrossRefGoogle Scholar
  4. Jia, B., Wu, Y., Li, B.Z., Mitchell, L.A., Liu, H., Pan, S., Wang, J., Zhang, H.R., Jia, N., Li, B., et al. (2018). Precise control of SCRaMbLE in synthetic haploid and diploid yeast. Nat Commun 9, 1933.CrossRefGoogle Scholar
  5. Koufos, A., Hansen, M.F., Copeland, N.G., Jenkins, N.A., Lampkin, B.C., and Cavenee, W.K. (1985). Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. Nature 316, 330–334.CrossRefGoogle Scholar
  6. Li, Y.X., Wu, Y., Ma, L., Guo, Z., Xiao, W.H., and Yuan, Y.J. (2019). Loss of heterozygosity by SCRaMbLEing. Sci China Life Sci 62, 381–393.CrossRefGoogle Scholar
  7. Liu, W., Luo, Z., Wang, Y., Pham, N.T., Tuck, L., Pérez-Pi, I., Liu, L., Shen, Y., French, C., Auer, M., et al. (2018). Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods. Nat Commun 9, 1936.CrossRefGoogle Scholar
  8. Luo, Z., Wang, L., Wang, Y., Zhang, W., Guo, Y., Shen, Y., Jiang, L., Wu, Q., Zhang, C., Cai, Y., et al. (2018). Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES. Nat Commun 9, 1930.CrossRefGoogle Scholar
  9. Shen, M.J., Wu, Y., Yang, K., Li, Y., Xu, H., Zhang, H., Li, B.Z., Li, X., Xiao, W.H., Zhou, X., et al. (2018). Heterozygous diploid and interspecies SCRaMbLEing. Nat Commun 9, 1934.CrossRefGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Shenzhen Key Laboratory of Synthetic Genomics and Center for Synthetic Genomics, Institute of Synthetic Biology, Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina

Personalised recommendations