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Surface-adaptive nanoparticles with near-infrared aggregation-induced emission for image-guided tumor resection

  • Xiaoyan Zhang
  • Cong Li
  • Wenyi Liu
  • Hanlin OuEmail author
  • Dan DingEmail author
Research Paper
  • 1 Downloads

Abstract

Aggregation-induced emission (AIE) nanoparticles (NPs) are widely used for image-guided tumor resection because of their high signal-to-noise ratios and long systemic circulation time. These NPs are derived by encapsulating small-molecule fluorescent dyes with AIE property inside the cores of NPs assembled by amphiphilic polymers. Although the systemic circulation of AIE NPs is prolonged, hydrophilic polymer coatings simultaneously decrease the binding and uptake of AIE NPs by tumor cells. To overcome this problem, surface-adaptive AIE dye-encapsulated mixed-shell micelles (MSMs) with polyethylene glycol/poly (β-amino ester) (PEG/PAE) surfaces were prepared. Due to the charge conversion ability of PAE, MSMs demonstrated enhanced cellular uptake by tumor cells in acidic conditions. In addition, compared with single-PEG-shelled micelles (PEGSMs), MSMs exhibited prolonged systemic circulation due to the presence of micro-phase separated surfaces. Moreover, due to the co-ordination effect of enhanced cancer cell uptake and prolonged systemic circulation time, MSMs were more enriched than PEGSMs in the tumor cells and exhibited excellent performance during image-guided tumor resection.

surface-adaptive enhanced cellular uptake image-guided tumor resection 

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Notes

Acknowledgements

This work was supported by the NSFC (51622305 and 51873092), the National Basic Research Program of China (2015CB856503), and the Fundamental Research Funds for the Central Universities, Nankai University (63191521, 63171218, and 63191176).

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References

  1. Alexis, F., Pridgen, E., Molnar, L.K., and Farokhzad, O.C. (2008). Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 5, 505–515.CrossRefGoogle Scholar
  2. Arvizo, R.R., Miranda, O.R., Thompson, M.A., Pabelick, C.M., Bhattacharya, R., Robertson, J.D., Rotello, V.M., Prakash, Y.S., and Mukherjee, P. (2010). Effect of nanoparticle surface charge at the plasma membrane and beyond. Nano Lett 10, 2543–2548.CrossRefGoogle Scholar
  3. Chen, C., Song, Z., Zheng, X., He, Z., Liu, B., Huang, X., Kong, D., Ding, D., and Tang, B.Z. (2017). AIEgen-based theranostic system: Targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel. Chem Sci 8, 2191–2198.CrossRefGoogle Scholar
  4. Chen, Y., and Shi, J. (2015). Mesoporous carbon biomaterials. Sci China Mater 58, 241–257.CrossRefGoogle Scholar
  5. Cheng, T., Zhang, Y., Liu, J., Ding, Y., Ou, H., Huang, F., An, Y., Liu, Y., Liu, J., and Shi, L. (2018). Ligand-switchable micellar nanocarriers for prolonging circulation time and enhancing targeting efficiency. ACS Appl Mater Interfaces 10, 5296–5304.CrossRefGoogle Scholar
  6. Cho, E.C., Xie, J., Wurm, P.A., and Xia, Y. (2009). Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant. Nano Lett 9, 1080–1084.CrossRefGoogle Scholar
  7. Fan, W., Qi, Y., Wang, R., Xu, C., Zhao, N., and Xu, F.J. (2018). Calcium carbonate-methylene blue nanohybrids for photodynamic therapy and ultrasound imaging. Sci China Life Sci 61, 483–491.CrossRefGoogle Scholar
  8. Gao, H., Cheng, T., Liu, J., Liu, J., Yang, C., Chu, L., Zhang, Y., Ma, R., and Shi, L. (2014). Self-regulated multifunctional collaboration of targeted nanocarriers for enhanced tumor therapy. Biomacromolecules 15, 3634–3642.CrossRefGoogle Scholar
  9. Gao, H., Zhang, X., Chen, C., Li, K., and Ding, D. (2018). Unity makes strength: How aggregation-induced emission luminogens advance the biomedical field. Adv Biosys 2, 1800074.CrossRefGoogle Scholar
  10. Gao, Y.J., Qiao, Z.Y., and Wang, H. (2016). Polymers with tertiary amine groups for drug delivery and bioimaging. Sci China Chem 59, 991–1002.CrossRefGoogle Scholar
  11. Gu, X., Zhang, X., Ma, H., Jia, S., Zhang, P., Zhao, Y., Liu, Q., Wang, J., Zheng, X., Lam, J.W.Y., et al. (2018). Corannulene-incorporated AIE nanodots with highly suppressed nonradiative decay for boosted cancer phototheranostics in vivo. Adv Mater 30, 1801065.CrossRefGoogle Scholar
  12. Hameed, S., Bhattarai, P., and Dai, Z. (2018). Nanotherapeutic approaches targeting angiogenesis and immune dysfunction in tumor microenvironment. Sci China Life Sci 61, 380–391.CrossRefGoogle Scholar
  13. Hong, Y., Lam, J.W.Y., and Tang, B.Z. (2011). Aggregation-induced emission. Chem Soc Rev 40, 5361–5388.CrossRefGoogle Scholar
  14. Jackson, A.M., Myerson, J.W., and Stellacci, F. (2004). Spontaneous assembly of subnanometre-ordered domains in the ligand shell of monolayer-protected nanoparticles. Nat Mater 3, 330–336.CrossRefGoogle Scholar
  15. Jiang, Y., and Pu, K. (2017). Advanced photoacoustic imaging applications of near-infrared absorbing organic nanoparticles. Small 13, 1700710.CrossRefGoogle Scholar
  16. Li, J., Ge, Z., and Liu, S. (2013). PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers. Chem Commun 49, 6974–6976.CrossRefGoogle Scholar
  17. Li, Y., Li, J., Chen, B., Chen, Q., Zhang, G., Liu, S., and Ge, Z. (2014). Polyplex micelles with thermoresponsive heterogeneous coronas for prolonged blood retention and promoted gene transfection. Biomacromolecules 15, 2914–2923.CrossRefGoogle Scholar
  18. Liu, J., Chen, C., Ji, S., Liu, Q., Ding, D., Zhao, D., and Liu, B. (2017). Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection. Chem Sci 8, 2782–2789.CrossRefGoogle Scholar
  19. Liu, S., Zhou, X., Zhang, H., Ou, H., Lam, J.W.Y., Liu, Y., Shi, L., Ding, D., and Tang, B.Z. (2019). Molecular motion in aggregates: Manipulating TICT for boosting photothermal theranostics. J Am Chem Soc 141, 5359–5368.CrossRefGoogle Scholar
  20. Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., et al. (2017). A STING-activating nanovaccine for cancer immunotherapy. Nat Nanotech 12, 648–654.CrossRefGoogle Scholar
  21. Mei, J., Leung, N.L.C., Kwok, R.T.K., Lam, J.W.Y., and Tang, B.Z. (2015). Aggregation-induced emission: Together we shine, united we soar! Chem Rev 115, 11718–11940.CrossRefGoogle Scholar
  22. Miao, Q., and Pu, K. (2016). Emerging designs of activatable photoacoustic probes for molecular imaging. Bioconjugate Chem 27, 2808–2823.CrossRefGoogle Scholar
  23. Nguyen, Q.T., Olson, E.S., Aguilera, T.A., Jiang, T., Scadeng, M., Ellies, L. G., and Tsien, R.Y. (2010). Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci USA 107, 4317–4322.CrossRefGoogle Scholar
  24. Ni, X., Zhang, X., Duan, X., Zheng, H.L., Xue, X.S., and Ding, D. (2019). Near-infrared afterglow luminescent aggregation-induced emission dots with ultrahigh tumor-to-liver signal ratio for promoted image-guided cancer surgery. Nano Lett 19, 318–330.CrossRefGoogle Scholar
  25. Qi, J., Fang, Y., Kwok, R.T.K., Zhang, X., Hu, X., Lam, J.W.Y., Ding, D., and Tang, B.Z. (2017). Highly stable organic small molecular nanoparticles as an advanced and biocompatible phototheranostic agent of tumor in living mice. ACS Nano 11, 7177–7188.CrossRefGoogle Scholar
  26. Ran, W., and Xue, X. (2018). Theranostical application of nanomedicine for treating central nervous system disorders. Sci China Life Sci 61, 392–399.CrossRefGoogle Scholar
  27. Romond, E.H., Perez, E.A., Bryant, J., Suman, V.J., Geyer, C.E., Davidson, N.E., Tan-Chiu, E., Martino, S., Paik, S., Kaufman, P.A., et al. (2005). Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353, 1673–1684.CrossRefGoogle Scholar
  28. Song, G., Liang, C., Yi, X., Zhao, Q., Cheng, L., Yang, K., and Liu, Z. (2016). Perfluorocarbon-loaded hollow Bi2Se3 nanoparticles for timely supply of oxygen under near-infrared light to enhance the radiotherapy of cancer. Adv Mater 28, 2716–2723.CrossRefGoogle Scholar
  29. Sun, Y., Bao, Y., Jiang, X., Tan, S., Yin, M., Yang, C., Zhou, L., and Zhang, Z. (2018). pH-sensitive micelles with charge-reversible property for tumor growth inhibition and anti-metastasis. J Mater Chem B 6, 458–468.CrossRefGoogle Scholar
  30. Torchilin, V. (2011). Tumor delivery of macromolecular drugs based on the EPR effect. Adv Drug Deliver Rev 63, 131–135.CrossRefGoogle Scholar
  31. Verma, A., and Stellacci, F. (2010). Effect of surface properties on nanoparticle-cell interactions. Small 6, 12–21.CrossRefGoogle Scholar
  32. Wei, H., Insin, N., Lee, J., Han, H.S., Cordero, J.M., Liu, W., and Bawendi, M.G. (2012). Compact zwitterion-coated iron oxide nanoparticles for biological applications. Nano Lett 12, 22–25.CrossRefGoogle Scholar
  33. Xiang, J., Wu, B., Zhou, Z., Hu, S., Piao, Y., Zhou, Q., Wang, G., Tang, J., Liu, X., and Shen, Y. (2018). Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy. Sci China Life Sci 61, 436–447.CrossRefGoogle Scholar
  34. Yang, X.Z., Du, J.Z., Dou, S., Mao, C.Q., Long, H.Y., and Wang, J. (2012). Sheddable ternary nanoparticles for tumor acidity-targeted siRNA delivery. ACS Nano 6, 771–781.CrossRefGoogle Scholar
  35. Zeng, C., Shang, W., Wang, K., Chi, C., Jia, X., Fang, C., Yang, D., Ye, J., Fang, C., and Tian, J. (2016). Intraoperative identification of liver cancer microfoci using a targeted near-infrared fluorescent probe for imaging-guided surgery. Sci Rep 6, 21959.CrossRefGoogle Scholar
  36. Zhang, H., Liu, X.L., Zhang, Y.F., Gao, F., Li, G.L., He, Y., Peng, M.L., and Fan, H.M. (2018). Magnetic nanoparticles based cancer therapy: Current status and applications. Sci China Life Sci 61, 400–414.CrossRefGoogle Scholar
  37. Zhang, X., and Zhang, H. (2018). Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME. Sci China Life Sci 61, 739–740.CrossRefGoogle Scholar
  38. Zhao, Z., Chen, C., Wu, W., Wang, F., Du, L., Zhang, X., Xiong, Y., He, X., Cai, Y., Kwok, R.T.K., et al. (2019). Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles. Nat Commun 10, 768.CrossRefGoogle Scholar
  39. Zheng, X., Mao, H., Huo, D., Wu, W., Liu, B., and Jiang, X. (2017). Successively activatable ultrasensitive probe for imaging tumour acidity and hypoxia. Nat Biomed Eng 1, 0057.CrossRefGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Bioactive Materials, Ministry of Education, College of Life SciencesNankai UniversityTianjinChina
  2. 2.Tianjin Stomatological Hospital, Hospital of Stomatology, Medical CollegeNankai UniversityTianjinChina
  3. 3.Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer InstituteXuzhou Medical UniversityXuzhouChina

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