Science China Life Sciences

, Volume 62, Issue 9, pp 1138–1143 | Cite as

Immunotherapy of hepatocellular carcinoma: strategies for combinatorial intervention

  • Mengxin Tian
  • Yinghong Shi
  • Weiren Liu
  • Jia FanEmail author
Review From CAS & CAE Members


Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, leading to 74.6 thousand deaths annually. The prognosis of HCC over the last few decades has remained unsatisfactory, and over half of patients with early-stage HCC develop recurrence by the time of follow-up. Immunotherapeutic intervention has emerged as a novel, effective treatment to delay the progression of aggressive tumors and suppress tumor recurrence and metastasis. However, few clinical immunotherapy trials have been conducted in HCC patients, and there is an unmet need for novel therapeutic strategies. The combination of conventional treatments with specific immunotherapeutic approaches may dramatically improve the efficacy of HCC treatment and the clinical outcome of HCC patients. In this review, we briefly summarize immunotherapy strategies and discuss new advances in combined immunotherapeutic approaches for the treatment of patients with liver cancer.

hepatocellular carcinoma immunotherapy immune checkpoint inhibitor strategy combination therapy 


Compliance and ethics The author(s) declare that they have no conflict of interest.


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Mengxin Tian
    • 1
    • 2
  • Yinghong Shi
    • 1
    • 2
  • Weiren Liu
    • 1
    • 2
  • Jia Fan
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Liver Surgery & Transplantation Center, Liver Cancer Institute, Zhongshan HospitalFudan UniversityShanghaiChina
  2. 2.Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of EducationShanghaiChina
  3. 3.Institute of Biomedical SciencesFudan UniversityShanghaiChina

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