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A lumbrokinase isozyme targets hepatitis B e-antigen

  • Yuan Zhou
  • Xiumei Wang
  • Shichao Fan
  • Rongqiao He
Open Access
Letter to the Editor

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (31470036). The funding bodies had no role in designing the study, or in data collection and analysis, the decision to publish, or in the preparation of this manuscript.

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References

  1. Fiorino, S., Bacchi-Reggiani, M.L., Leandri, P., Loggi, E., and Andreone, P. (2017). Vitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: A systematic review and metaanalysis. WJH 9, 333–342.CrossRefGoogle Scholar
  2. Jung, M.C., Diepolder, H.M., Spengler, U., Wierenga, E.A., Zachoval, R., Hoffmann, R.M., Eichenlaub, D., Frosner, G., Will, H., and Pape, G.R. (1995). Activation of a heterogeneous hepatitis-B (Hb) core and eantigen-specific CD4(+) T-Cell population during seroconversion to anti-Hbe and anti-Hbs in hepatitis-B virus-infection. J Virol 69, 3358–3368.Google Scholar
  3. Laras, A., Koskinas, J., Dimou, E., Kostamena, A., and Hadziyannis, S.J. (2006). Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients. Hepatology 44, 694–702.CrossRefGoogle Scholar
  4. Li, S., Bao, X., Wang, D., You, L., Li, X., Yang, H., Bian, J., Wang, Y., and Yang, Y. (2017). APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells. Sci China Life Sci 60, 617–626.CrossRefGoogle Scholar
  5. Li, S.Z. (1999). Earthworm in Compendium of Materia Medica, Edited by Wang, Y.J. (People′s Medical Publishing House, Beijing), pp.2100–2104.Google Scholar
  6. Mo, W.C., Zhao, J., Liu, Y., and He, R.Q. (2018). Nanozyme also acts in enzyme-like denaturation? Prog Biochem Biophys 45, 268–271.Google Scholar
  7. Nakajima, N., Sugimoto, M., and Ishihara, K. (2003). Earthworm-serine protease: characterization, molecular cloning, and application of the catalytic functions. J Mol Catal B-Enzymatic 23, 191–212.CrossRefGoogle Scholar
  8. Peng, H., and Tian, Z. (2016). Tissue-resident natural killer cells in the livers. Sci China Life Sci 59, 1218–1223.CrossRefGoogle Scholar
  9. Sells, M.A., Chen, M.L., and Acs, G. (1987). Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci USA 84, 1005–1009.CrossRefGoogle Scholar
  10. Wang, X.M., Fan, S.C., Chen, Y., Ma, X.F., and He, R.Q. (2018). Earthworm protease in anti-thrombosis and anti-fibrosis. Biochem Biophys Acta-GS https://doi.org/10.1016/j.bbagen.2018.11.006.Google Scholar
  11. Wu, J.F., Chiu, Y.C., Chang, K.C., Chen, H.L., Ni, Y.H., Hsu, H.Y., and Chang, M.H. (2016). Predictors of hepatitis B e antigen-negative hepatitis in chronic hepatitis B virus-infected patients from childhood to adulthood. Hepatology 63, 74–82.CrossRefGoogle Scholar
  12. Wu, J.X., Zhao, X.Y., Pan, R., and He, R.Q. (2007). Glycosylated trypsinlike proteases from earthworm Eisenia fetida. Int J Biol Macromolecules 40, 399–406.CrossRefGoogle Scholar
  13. Wu, X., and Tian, Z. (2017). Gut-liver axis: gut microbiota in shaping hepatic innate immunity. Sci China Life Sci 60, 1191–1196.CrossRefGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yuan Zhou
    • 1
  • Xiumei Wang
    • 1
  • Shichao Fan
    • 1
  • Rongqiao He
    • 1
  1. 1.Institute of BiophysicsUniversity of Chinese Academy of SciencesBeijingChina

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