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Science China Life Sciences

, Volume 61, Issue 12, pp 1465–1473 | Cite as

Vaccination of poultry successfully eliminated human infection with H7N9 virus in China

  • Xianying Zeng
  • Guobin Tian
  • Jianzhong Shi
  • Guohua Deng
  • Chengjun Li
  • Hualan Chen
Review From CAS & CAE Members

Abstract

The H7N9 viruses that emerged in China in 2013 were nonpathogenic in chickens but mutated to a highly pathogenic form in early 2017 and caused severe disease outbreaks in chickens. The H7N9 influenza viruses have caused five waves of human infection, with almost half of the total number of human cases (766 of 1,567) being reported in the fifth wave, raising concerns that even more human infections could occur in the sixth wave. In September 2017, an H5/H7 bivalent inactivated vaccine for chickens was introduced, and the H7N9 virus isolation rate in poultry dropped by 93.3% after vaccination. More importantly, only three H7N9 human cases were reported between October 1, 2017 and September 30, 2018, indicating that vaccination of poultry successfully eliminated human infection with H7N9 virus. These facts emphasize that active control of animal disease is extremely important for zoonosis control and human health protection.

Keywords

H7N9 influenza virus evolution vaccination human infection elimination 

Notes

Acknowledgements

This work was supported by the National Key R&D Program of China (2016YFD0500201, 2016YFD0500203), the National Natural Science Foundation of China (31521005), and the China Agriculture Research System (CARS-41-G12).

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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Xianying Zeng
    • 1
  • Guobin Tian
    • 1
  • Jianzhong Shi
    • 1
  • Guohua Deng
    • 1
  • Chengjun Li
    • 1
  • Hualan Chen
    • 1
  1. 1.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbinChina

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