Science China Life Sciences

, Volume 62, Issue 6, pp 807–815 | Cite as

Dysbiosis of gut microbiota was closely associated with psoriasis

  • Linsheng Huang
  • Renyuan Gao
  • Ning Yu
  • Yefei Zhu
  • Yangfeng DingEmail author
  • Huanlong QinEmail author
Research Paper


Psoriasis is an autoimmune disease and gut microbiota participate in the establishment of intestinal immunity. This study was performed to identify the fecal microbial composition of psoriasis patients, and investigated the influence of subgroup (type and severity) on the fecal microbial composition, and to define the key microbiota in the pathogenesis of psoriasis. Fecal samples from 35 psoriasis patients and 27 healthy controls were sequenced by 16S rRNA and then analyzed by informatics methods. We found that the microbiota of the psoriasis group differed from that of the heathy group. The relative abundances of Firmicutes and Bacteroidetes were inverted at the phylum level, and 16 kinds of phylotype at the genus level were found with significant difference. No microbial diversity and composition alteration were observed among the four types of psoriasis. The microbiota of psoriasis patients in the severe state differs from those of psoriasis patients with more mild conditions and also the healthy controls. The veillonella in fecal microbiota showed a positive relationship with h-CRP in blood. This research proved that psoriasis patients have a significant disturbed microbiota profiles. Further study of psoriasis based on microbiota may provide novel insights into the pathogenesis of psoriasis and more evidence for the prevention and treatment of psoriasis.


dysbiosis gut microbiota psoriasis severity 


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We thank Majorbio Biological Technology Co., Ltd. for providing technical assistance in this study. This work was supported by the National Natural Science Foundation of China (81230057, 81200264, 81372615, 81472262), the Emerging Cutting-Edge Technology Joint Research Projects of Shanghai (SHDC12012106) and the Tongji University Subject Pilot Program (162385).

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  1. Alunno, A., Carubbi, F., Cafaro, G., Pucci, G., Battista, F., Bartoloni, E., Giacomelli, R., Schillaci, G., and Gerli, R. (2015). Targeting the IL-23/IL-17 axis for the treatment of psoriasis and psoriatic arthritis. Expert Opin Biol Ther 15, 1727–1737.CrossRefGoogle Scholar
  2. Armstrong, A.W., Robertson, A.D., Wu, J., Schupp, C., and Lebwohl, M.G. (2013). Undertreatment, treatment trends, and treatment dissatisfaction among patients with psoriasis and psoriatic arthritis in the United States. JAMA Dermatol 149, 1180–1185.CrossRefGoogle Scholar
  3. Bhatia, B.K., Millsop, J.W., Debbaneh, M., Koo, J., Linos, E., and Liao, W. (2014). Diet and psoriasis, part II: celiac disease and role of a glutenfree diet. J Am Acad Dermatol 71, 350–358.CrossRefGoogle Scholar
  4. Boehncke, W.H., and Schön, M.P. (2015). Psoriasis. Lancet 386, 983–994.CrossRefGoogle Scholar
  5. Chimenti, M.S., Ballanti, E., Perricone, C., Cipriani, P., Giacomelli, R., and Perricone, R. (2013). Immunomodulation in psoriatic arthritis: focus on cellular and molecular pathways. Autoimmun Rev 12, 599–606.CrossRefGoogle Scholar
  6. Debbaneh, M., Millsop, J.W., Bhatia, B.K., Koo, J., and Liao, W. (2014). Diet and psoriasis, part I: Impact of weight loss interventions. J Am Acad Dermatol 71, 133–140.CrossRefGoogle Scholar
  7. Di Cesare, A., Di Meglio, P., and Nestle, F.O. (2009). The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 129, 1339–1350.CrossRefGoogle Scholar
  8. Di Meglio, P., Duarte, J.H., Ahlfors, H., Owens, N.D.L., Li, Y., Villanova, F., Tosi, I., Hirota, K., Nestle, F.O., Mrowietz, U., et al. (2014). Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions. Immunity 40, 989–1001.CrossRefGoogle Scholar
  9. Doaa, M., Dalia, M., and Ahmed, F.S. (2016). Gut bacterial microbiota in psoriasis: a case control study. Afr J Microbiol Res 10, 1337–1343.CrossRefGoogle Scholar
  10. Drago, F., Ciccarese, G., Indemini, E., Savarino, V., and Parodi, A. (2018). Psoriasis and small intestine bacterial overgrowth. Int J Dermatol 57, 112–113.CrossRefGoogle Scholar
  11. Eppinga, H., Konstantinov, S.R., Peppelenbosch, M.P., and Thio, H.B. (2014). The microbiome and psoriatic arthritis. Curr Rheumatol Rep 16, 407.CrossRefGoogle Scholar
  12. Eppinga, H., Sperna Weiland, C.J., Thio, H.B., van der Woude, C.J., Nijsten, T.E.C., Peppelenbosch, M.P., and Konstantinov, S.R. (2016). Similar depletion of protective Faecalibacterium prausnitzii in psoriasis and inflammatory bowel disease, but not in hidradenitis suppurativa. J Crohns Colitis 10, 1067–1075.CrossRefGoogle Scholar
  13. Felix, K.M., Tahsin, S., and Wu, H.J.J. (2017). Host-microbiota interplay in mediating immune disorders. Ann NY Acad Sci 1417, 57–70.CrossRefGoogle Scholar
  14. Fry, L., Baker, B.S., Powles, A.V., and Engstrand, L. (2015). Psoriasis is not an autoimmune disease? Exp Dermatol 24, 241–244.CrossRefGoogle Scholar
  15. Gao, R., Zhu, C., Li, H., Yin, M., Pan, C., Huang, L., Kong, C., Wang, X., Zhang, Y., Qu, S., et al. (2018). Dysbiosis signatures of gut microbiota along the sequence from healthy, young patients to those with overweight and obesity. Obesity (Silver Spring) 26, 351–361.CrossRefGoogle Scholar
  16. Gevers, D., Kugathasan, S., Denson, L.A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S.J., Yassour, M., et al. (2014). The treatment-naive microbiome in new-onset Crohn’s disease. Cell Host Microbe 15, 382–392.CrossRefGoogle Scholar
  17. Hsu, L., and Armstrong, A.W. (2014). JAK inhibitors: treatment efficacy and safety profile in patients with psoriasis. J Immunol Res 2014, 1–7.CrossRefGoogle Scholar
  18. Kamada, N., and Núñez, G. (2014). Regulation of the immune system by the resident intestinal bacteria. Gastroenterology 146, 1477–1488.CrossRefGoogle Scholar
  19. Karolewska-Bochenek, K., Grzesiowski, P., Banaszkiewicz, A., Gawronska, A., Kotowska, M., Dziekiewicz, M., Albrecht, P., Radzikowski, A., and Lazowska-Przeorek, I. (2018). A two-week fecal microbiota transplantation course in pediatric patients with inflammatory bowel disease. Adv Exp Med Biol 1047, 81–87.CrossRefGoogle Scholar
  20. Mashima, I., and Nakazawa, F. (2014). The influence of oral Veillonella species on biofilms formed by Streptococcus species. Anaerobe 28, 54–61.CrossRefGoogle Scholar
  21. Nestle, F.O., Kaplan, D.H., and Barker, J. (2009). Psoriasis. N Engl J Med 361, 496–509.CrossRefGoogle Scholar
  22. Parisi, R., Symmons, D.P.M., Griffiths, C.E.M., Ashcroft, D.M., and Ashcroft, D.M. (2013). Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol 133, 377–385.CrossRefGoogle Scholar
  23. Purchiaroni, F., Tortora, A., Gabrielli, M., Bertucci, F., Gigante, G., Ianiro, G., Ojetti, V., Scarpellini, E., and Gasbarrini, A. (2013). The role of intestinal microbiota and the immune system. Eur Rev Med Pharmacol Sci 17, 323–333.Google Scholar
  24. Scher, J.U., Ubeda, C., Artacho, A., Attur, M., Isaac, S., Reddy, S.M., Marmon, S., Neimann, A., Brusca, S., Patel, T., et al. (2015). Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthr Rheumatol 67, 128–139.CrossRefGoogle Scholar
  25. Tan, L.R., Zhao, S., Zhu, W., Wu, L., Li, J., Shen, M.X., Lei, L., Chen, X., and Peng, C. (2018). The Akkermansia muciniphila is a gut microbiota signature in psoriasis. Exp Dermatol 27, 144–149.CrossRefGoogle Scholar
  26. Wu, X., and Tian, Z. (2017). Gut-liver axis: gut microbiota in shaping hepatic innate immunity. Sci China Life Sci 60, 1191–1196.CrossRefGoogle Scholar
  27. Yan, D., Issa, N., Afifi, L., Jeon, C., Chang, H.W., and Liao, W. (2017). The role of the skin and gut microbiome in psoriatic disease. Curr Derm Rep 6, 94–103.CrossRefGoogle Scholar
  28. Yoshino, Y., Kitazawa, T., Ikeda, M., Tatsuno, K., Yanagimoto, S., Okugawa, S., Ota, Y., and Yotsuyanagi, H. (2012). Clinical features of Bacteroides bacteremia and their association with colorectal carcinoma. Infection 40, 63–67.CrossRefGoogle Scholar
  29. Zákostelská, Z., Málková, J., Klimešová, K., Rossmann, P., Hornová, M., Novosádová, I., Stehlíková, Z., Kostovcík, M., Hudcovic, T., Štepánková, R., et al. (2016). Intestinal microbiota promotes psoriasis-like skin inflammation by enhancing Th17 response. PLoS ONE 11, e015–9539.CrossRefGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Shanghai Clinical CollegeAnhui Medical UniversityShanghaiChina
  2. 2.Department of General SurgeryShanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghaiChina
  3. 3.Department of DermatologyShanghai Dermatology HospitalShanghaiChina

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