Science China Life Sciences

, Volume 61, Issue 9, pp 1118–1119 | Cite as

Is it really the “dark side” of herbal medicine?

  • Yang LuanEmail author
  • Shuangcheng Ma
  • Yimin Mao


  1. Chen, Z., and Chen, S.J. (2017). Poisoning the devil. Cell 168, 556–560.CrossRefPubMedGoogle Scholar
  2. Hollstein, M., Marion, M.J., Lehman, T., Welsh, J., Harris, C.C., Martel-Planche, G., Kusters, I., and Montesano, R. (1994). p53 mutations at A: T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis 15, 1–3.CrossRefPubMedGoogle Scholar
  3. Ng, A.W.T., Poon, S.L., Huang, M.N., Lim, J.Q., Boot, A., Yu, W., Suzuki, Y., Thangaraju, S., Ng, C.C.Y., Tan, P., et al. (2017). Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. Sci Transl Med 9, eaan6446.CrossRefPubMedGoogle Scholar
  4. Park, J.W., Chen, M., Colombo, M., Roberts, L.R., Schwartz, M., Chen, P. J., Kudo, M., Johnson, P., Wagner, S., Orsini, L.S., et al. (2015). Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE study. Liver Int 35, 2155–2166.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Schmeiser, H.H., Nortier, J.L., Singh, R., Gamboa da Costa, G., Sennesael, J., Cassuto-Viguier, E., Ambrosetti, D., Rorive, S., Pozdzik, A., Phillips, D.H., et al. (2014). Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy. Int J Cancer 135, 502–507.CrossRefPubMedGoogle Scholar
  6. Shibutani, S., Dong, H., Suzuki, N., Ueda, S., Miller, F., and Grollman, A.P. (2007). Selective toxicity of aristolochic acids I and II. Drug Metab Disposit 35, 1217–1222.CrossRefGoogle Scholar
  7. Sills, R.C., Hong, H.L., Melnick, R.L., Boorman, G.A., and Devereux, T.R. (1999). High frequency of codon 61 K-ras A→T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene. Carcinogenesis 20, 657–662.CrossRefPubMedGoogle Scholar
  8. Stiborová, M., Arlt, V.M., and Schmeiser, H.H. (2017). DNA adducts formed by aristolochic acid are unique biomarkers of exposure and explain the initiation phase of upper urothelial cancer. Int J Mol Sci 18, 2144.CrossRefPubMedCentralGoogle Scholar
  9. Wagoner, J.K. (1983). Toxicity of vinyl chloride and poly(vinyl chloride): a critical review. Environ Health Perspect 52, 61–66.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Xing, G., Qi, X., Chen, M., Wu, Y., Yao, J., Gong, L., Nohmi, T., Luan, Y., and Ren, J. (2012). Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res 743, 52–58.CrossRefPubMedGoogle Scholar
  11. Zhang, W., He, H., Zang, M., Wu, Q., Zhao, H., Lu, L.L., Ma, P., Zheng, H., Wang, N., Zhang, Y., et al. (2017). Genetic features of aflatoxinassociated hepatocellular carcinoma. Gastroenterology 153, 249–262. e2.CrossRefPubMedGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Faculty of Public HealthShanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.National Institutes for Food and Drug ControlBeijingChina
  3. 3.Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Personalised recommendations