Science China Life Sciences

, Volume 61, Issue 10, pp 1137–1150 | Cite as

Chemical modulation of cell fates: in situ regeneration

  • Hua Qin
  • Andong Zhao
  • Xiaobing FuEmail author


Chemical modulation of cell fates has been widely used to promote tissue and organ regeneration. Small molecules can target the self-renewal, expansion, differentiation, and survival of endogenous stem cells for enhancing their regenerative power or induce dedifferentiation or transdifferentiation of mature cells into proliferative progenitors or specialized cell types needed for regeneration. Here, we discuss current progress and potential using small molecules to promote in vivo regenerative processes by regulating the cell fate. Current studies of small molecules in regeneration will provide insights into developing safe and efficient chemical approaches for in situ tissue repair and regeneration.


small molecule in situ regeneration adult stem cells somatic cells dedifferentiation transdifferentiation reprogramming 


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This work was supported by the National Natural Science Foundation of China (81721092) and the National Key R&D Program of China (2017YFC1103304).


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Graduate School of Tianjin Medical UniversityTianjinChina
  2. 2.Cell Biology and Tissue Repair LaboratoryKey Laboratory of Wound Repair and Regeneration of PLA, the First Hospital Affiliated to the PLA General HospitalBeijingChina
  3. 3.College of Life SciencesPLA General Hospital, PLA Medical CollegeBeijingChina

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