Science China Life Sciences

, Volume 61, Issue 10, pp 1280–1282 | Cite as

A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice

  • Peihua Niu
  • Guangyu Zhao
  • Yao Deng
  • Shihui Sun
  • Wenling Wang
  • Yusen ZhouEmail author
  • Wenjie TanEmail author
Letter to the Editor


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.



We thank Dr. Bart L. Haagmans and Dr. Ron A.M. Fouchier (Erasmus MC, Rotterdam, the Netherlands) for providing MERSCoV (isolate hCoV-EMC/2012). This work was supported by the National Key Research and Development Program of China (2016YFD0500300 to Wenjie Tan). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Supplementary material

11427_2018_9343_MOESM1_ESM.docx (326 kb)
Supporting Information


  1. Agrawal, A.S., Ying, T., Tao, X., Garron, T., Algaissi, A., Wang, Y., Wang, L., Peng, B.H., Jiang, S., Dimitrov, D.S., et al. (2016). Passive transfer of A germline-like neutralizing human monoclonal antibody protects transgenic mice against lethal middle east respiratory syndrome coronavirus infection. Sci Rep 6, 31629.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Qiu, H., Sun, S., Xiao, H., Feng, J., Guo, Y., Tai, W., Wang, Y., Du, L., Zhao, G., and Zhou, Y. (2016). Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection. Antiviral Res 132, 141–148.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Shi, W., Li, J., Zhou, H., and Gao, G.F. (2017). Pathogen genomic surveillance elucidates the origins, transmission and evolution of emerging viral agents in China. Sci China Life Sci 60, 1317–1330.CrossRefPubMedGoogle Scholar
  4. Smith, K., Garman, L., Wrammert, J., Zheng, N.Y., Capra, J.D., Ahmed, R., and Wilson, P.C. (2009). Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nat Protoc 4, 372–384.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Ying, T., Du, L., Ju, T.W., Prabakaran, P., Lau, C.C.Y., Lu, L., Liu, Q., Wang, L., Feng, Y., Wang, Y., et al. (2014). Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies. J Virol 88, 7796–7805.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D.M.E., and Fouchier, R.A.M. (2012). Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 367, 1814–1820.CrossRefPubMedGoogle Scholar
  7. Zhao, G., Du, L., Ma, C., Li, Y., Li, L., Poon, V.K., Wang, L., Yu, F., Zheng, B.J., Jiang, S., et al. (2013). A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV. Virol J 10, 266.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina
  2. 2.State Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and EpidemiologyBeijingChina

Personalised recommendations