Science China Life Sciences

, Volume 61, Issue 11, pp 1437–1438 | Cite as

A role of IL-25, a sibling of IL-17, in triggering psoriatic skin inflammation

  • Xuemei TongEmail author
  • Bin LiEmail author
Research Highlight


  1. Beringer, A., Noack, M., and Miossec, P. (2016). IL-17 in chronic inflammation: from discovery to targeting. Trends Mol Med 22, 230–241.CrossRefPubMedGoogle Scholar
  2. Gronke, K., and Diefenbach, A. (2016). Tuft cell-derived IL-25 activates and maintains ILC2. Immunol Cell Biol 94, 221–223.CrossRefPubMedGoogle Scholar
  3. Iwakura, Y., Ishigame, H., Saijo, S., and Kakae, S. (2011). Functional specialization of interleukin-17 family members. Immunity 34, 149–162.CrossRefPubMedGoogle Scholar
  4. Kim, J., and Krueger, J.G. (2017). Highly effective new treatments for psoriasis target the IL-23/Type 17 T cell autoimmune axis. Annu Rev Med 68, 255–269.CrossRefPubMedGoogle Scholar
  5. Kumari, S., Bonnet, M.C., Ulvmar, M.H., Wolk, K., Karagiannni, N., Witte, E., Uthoff-Hachenberg, C., Renauld, J. C., Kollias, G., Toftgard, R., et al. (2013). Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity 39, 899–911.CrossRefPubMedGoogle Scholar
  6. Lowes, M.A., Suárez-Fariñas, M., and Krueger, J.G. (2014). Immunology of psoriasis. Annu Rev Immunol 32, 227–255.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Pasparakis, M., Haase, I., and Nestle, F.O. (2014). Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol 14, 289–301.CrossRefPubMedGoogle Scholar
  8. Reynolds, J.M., Lee, Y.H., Shi, Y., Wang, X., Angkasekwinai, P., Nallaparaju, K.C., Flaherty, S., Chang, S.H., Watarai, H., and Dong, C., (2015). Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation. Immunity 42, 692–703.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Tong, X., and Coulombe, P.A. (2006). Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev 20, 1353–1364.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Xu, M., Lu, H., Lee, Y.H., Wu, Y., Liu, K., Shi, Y., An, Y., Zhang, J., Wang, Y., Lai, Y., et al. (2018). An interleukin-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. Immunity 48, 787–798.e4.CrossRefPubMedGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.Shanghai Institute of ImmunologyShanghai Jiao Tong University School of MedicineShanghaiChina
  3. 3.Department of Immunology and MicrobiologyShanghai Jiao Tong University School of MedicineShanghaiChina

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