Effect of nanoheat stimulation mediated by magnetic nanocomposite hydrogel on the osteogenic differentiation of mesenchymal stem cells

Research Paper Thematic Issue: Nanotechnology and nanomedicine


Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic Fe3O4 nanoparticles into chitosan/polyethylene glycol (PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field (AMF). With uniformly dispersed nanoparticles, the composite hydrogel resulted in high viability of mesenchymal stem cells (MSCs), and the elevated temperature contributed to the highest osteogenic differentiation ability compared with direct heat treatment applied under equal temperatures. Therefore, the nanoheat stimulation method using the magnetic nanocomposite hydrogel under an AMF may be considered as an alternative candidate in bone tissue engineering regenerative applications.


temperature magnetic nanocomposite hydrogel mesenchymal stem cell osteogenic differentiation 


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The authors are grateful for the financial support from the National Natural Science Foundation of China (81671829) and the 111 Project (B17026).


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Zheng Cao
    • 1
    • 2
  • Dan Wang
    • 1
    • 2
  • Yongsan Li
    • 3
    • 4
  • Wensheng Xie
    • 1
    • 2
  • Xing Wang
    • 4
  • Lei Tao
    • 3
  • Yen Wei
    • 3
  • Xiumei Wang
    • 1
    • 2
  • Lingyun Zhao
    • 1
    • 2
  1. 1.State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and EngineeringTsinghua UniversityBeijingChina
  2. 2.School of Materials Science and EngineeringTsinghua UniversityBeijingChina
  3. 3.Department of ChemistryTsinghua UniversityBeijingChina
  4. 4.The State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijingChina

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