Probing the kinetics in supramolecular chemistry and molecular assembly by microfluidic-NMR spectroscopy
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Microfluidic-NMR spectroscopy has been extended to study the kinetics in supramolecular chemistry and molecular assembly. Kinetics of a multicomponent host-guest supramolecular system containing viologen derivatives, β-cyclodextrins and cucurbit urils are studied by a PMMA based microfluidic chip combined with a dedicated transmission line probe for NMR detection. By combining microfluidic technology with NMR spectroscopy, the amount of material required for a full kinetic study could be minimized. This is crucial in supramolecular chemistry, which often involves highly sophisticated and synthetically costly building blocks. The small size of the microfluidic structure is crucial in bringing the time scale for kinetic monitoring down to seconds. At the same time, the transmission line NMR probe provides sufficient sensitivity to work at low (2 mM) concentrations.
Keywordsmicrofluidic-NMR molecular assembly host-guest chemistry kinetics
This work was supported by the National Basic Research Program of China (2015CB856500), the National Natural Science Foundation of China (21722304, 21573181, 91227111, 91427304) and the Fundamental Research Funds for the Central Universities of China (20720160050). Development and Construction of the NMR probe was supported in part by a Marie Curie Career Integration Grant to MU by the European Commission (Project uf-NMR). We thank Billy Hale for the help on the bonding protocol of microfluidic chip, Chen Jia-He for the help on NMR data acquirement, Chai Hong-Xin and Li Ming-Shuang for the ITC data acquirement, Lin Dong-Hai and Yao Hong-Wei for discussions.