Oxidation-induced ortho-selective C–H bond functionalization of 2-naphthylamine derivative
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Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group (DG)-assisted C–H bond activation was developed as one of the most efficient methods for selective C–H functionalization. Although a great progress has been made by utilizing this traditional method, developing new strategy for selective C–H bond functionalization is still highly demanded. Hence, a novel oxidation-induced C–H bond functionalization method was demonstrated in this work. By this new method, ortho-C(sp2)–H chlorination of N-substituted 2-naphthylamine was realized in a highly selective manner.
Keywordsoxidation-induced C–H bond functionalization ortho-selectivity
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This work was supported by the National Natural Science Foundation of China (21390402, 21520102003, 21702150), the National Basic Research Program of China (2012CB725302), the CAS Interdisciplinary Innovation Team and the Hubei Province Natural Science Foundation of China (2017CFA010), and China Postdoctoral Science Foundation (BX201600114, 2016M602340). XAS study was performed at National Synchrotron Radiation Research Center. The Program of Introducing Talents of Discipline to Universities of China is also appreciated.
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