Advertisement

Osteointegration in Compliant Self-Adjusting Compression Fixation Shown by Backscatter Electron Microscopy: A Case Report

  • Alexander B. ChristEmail author
  • Elexis Baral
  • Timothy M. Wright
  • John H. Healey
Case Report

Abstract

Compliant self-adjusting compression implants are a novel approach to increase the durability of megaprosthesis fixation. However, there is no report of current implant designs that documents the bone-prosthetic interface of this implant. A well-fixed compliant, self-adjusting distal femoral replacement was retrieved from a patient undergoing revision unrelated to fixation. The prosthesis-bone interface was preserved, embedded in poly(methyl methacrylate), and sectioned into 2–4-mm slices. Slices were then imaged using backscatter electron microscopy, and ongrowth and ingrowth were quantified using imaging software. The average percentage of bony ongrowth from five successive sections was 52.5%, and the average percentage of ingrowth into the porous titanium surface was 13.5%. We found that bone ongrowth on the cortex between anchor plug and spindle averages more than 50% and up to 70% depending upon the slice examined with backscatter electron microscopy. Bone ingrowth was consistently around 13% on every slice examined. This is a new finding compared with prior spindle designs, likely due to the addition of hydroxyapatite-coated porous metal titanium surface on the spindle. This report is an important step in understanding the mechanism of bony fixation generated by this implant and supports its increased use in oncological and complex reconstructive situations.

Keywords

megaprosthesis osteointegration compliant self-adjusting compression fixation retrieval analysis backscatter electron microscopy 

Notes

Compliance with Ethical Standards

Conflict of Interest

Alexander B. Christ, MD, and Elexis Baral, BS, declare that they have no conflicts of interest. Timothy M. Wright, PhD, reports research support from Stryker, stock options from Orthobond, intellectual property royalties from Mathys Ltd. and from Exactech, and intellectual property royalties and research support from Lima Corporate, as well as board membership in the Knee Society, outside the submitted work. John H. Healey, MD, reports being a paid consultant to Daiichi Sanyo and Stryker, outside the submitted work.

Human/Animal Rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2013.

Informed Consent

Informed consent was waived from the patient for being included in this study.

Required Author Forms:

Disclosure forms provided by the authors are available with the online version of this article.

References

  1. 1.
    Abrams GD, Gajendran VK, Mohler DG, Avedian RS. Surgical technique: methods for removing a Compress compliant prestress implant. Clin Orthop Related Res. 2012;470(4):1204–1212.  https://doi.org/10.1007/s11999-011-2128-z CrossRefGoogle Scholar
  2. 2.
    Bini SA, Johnston JO, Martin DL. Compliant prestress fixation in tumor prostheses: interface retrieval data. Orthopedics. 2000;23(7):702–707.Google Scholar
  3. 3.
    Bruns J, Delling G, Gruber H, Lohmann CH, Habermann CR. Cementless fixation of megaprostheses using a conical fluted stem in the treatment of bone tumours. J Bone Joint Surg Br. 2007;89(8), 1084–1087.  https://doi.org/10.1302/0301-620X.89B8.19236 CrossRefGoogle Scholar
  4. 4.
    Capanna R, Scoccianti G, Frenos F, Vilardi A, Beltrami G, Campanacci DA. What was the survival of megaprostheses in lower limb reconstructions after tumor resections? Clin Orthop Related Res. 2014;473(3):820–830.  https://doi.org/10.1007/s11999-014-3736-1 CrossRefGoogle Scholar
  5. 5.
    Ferguson PC, Zdero R, Schemitsch EH, Deheshi BM, Bell RS, Wunder JS. A biomechanical evaluation of press-fit stem constructs for tumor endoprosthetic reconstruction of the distal femur. J Arthroplasty. 2011;26(8):1373–1379.  https://doi.org/10.1016/j.arth.2010.12.005 CrossRefGoogle Scholar
  6. 6.
    Healey JH, Morris CD, Athanasian EA, Boland PJ. Compress knee arthroplasty has 80% 10-year survivorship and novel forms of bone failure. Clin Orthop Related Res. 2013;471(3):774–783.  https://doi.org/10.1007/s11999-012-2635-6 CrossRefGoogle Scholar
  7. 7.
    Pala E, Trovarelli G, Calabrò T, Angelini A, Abati CN, Ruggieri P. Survival of modern knee tumor megaprostheses: failures, functional results, and a comparative statistical analysis. Clin Orthop Related Res. 2015;473(3):891–899.  https://doi.org/10.1007/s11999-014-3699-2 CrossRefGoogle Scholar
  8. 8.
    Palumbo BT, Henderson ER, Groundland JS, et al. Advances in segmental endoprosthetic reconstruction for extremity tumors: a review of contemporary designs and techniques. Cancer Control. 2011;18(3):160–170.CrossRefGoogle Scholar
  9. 9.
    Zimel MN, Farfalli GL, Zindman AM, et al. Revision distal femoral arthroplasty with the Compress prosthesis has a low rate of mechanical failure at 10 years. Clin Orthop Related Res. 2016;474(2):528–536.  https://doi.org/10.1007/s11999-015-4552-y CrossRefGoogle Scholar
  10. 10.
    Avedian RS, Goldsby RE, Kramer MJ, O’Donnell RJ. Effect of chemotherapy on initial compressive osseointegration of tumor endoprostheses. Clin Orthop Relat Res. 2007;459:48–53.CrossRefGoogle Scholar

Copyright information

© Hospital for Special Surgery 2019

Authors and Affiliations

  1. 1.Division of Adult Reconstruction and Joint ReplacementHospital for Special SurgeryNew YorkUSA
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Department of BiomechanicsHospital for Special SurgeryNew YorkUSA

Personalised recommendations