Surface adsorption of cannabinoids in LC–MS/MS applications

  • Jon B. StephensonEmail author
  • Denise N. Carter
  • Mario Richardson
Letter to the Editor

Dear Editor

Adsorption of cannabinoids to different materials has been documented in various different conditions [1, 2, 3, 4, 5, 6, 7, 8, 9, 10]. It is an aspect that can be easily overlooked during the validation of a cannabinoid analysis procedure. During the validation of such a procedure at the Georgia Bureau of Investigation, it was determined that the final reconstitution step before instrumental analysis by liquid chromatography—tandem mass spectrometry (LC–MS/MS) was sensitive to this effect and needed further examination. A study was conducted to measure the effects of a solution and adsorption to glass test tubes during this final step of the procedure.

Up to now most papers on this topic have focused on the materials used during storage of samples such as plastic and glass containers or materials used in a cannabinoid testing procedure such as pipette tips and glass test tubes [1, 2, 3, 4, 5, 6, 7, 8, 9, 10]. The typical approach seems to be combating surface adsorption by...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Japanese Association of Forensic Toxicology 2019

Authors and Affiliations

  1. 1.Georgia Bureau of Investigation Division of Forensic SciencesDecaturUSA

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