Forensic Toxicology

, Volume 37, Issue 1, pp 250–253 | Cite as

Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8

  • Yoshiaki IwamuroEmail author
  • Takaya Murakami
  • Reiko Ishimaru
  • Satoshi Chinaka
Case Report



This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery.


The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS).


The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities.


When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated.


Muscle relaxant Rocuronium Muscle relaxant reversal agent Sugammadex LC/MS 


Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethical standards

This article does not contain any studies involving living human participants or animals performed by any of the authors.


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Copyright information

© Japanese Association of Forensic Toxicology and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Forensic Science LaboratoryIshikawa Prefectural Police HeadquartersKanazawaJapan

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