Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity
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One novel neoligan glucoside, Ginkgoside B (1), and one new glucose ester, 6-O-(4-hydroxyhydrocinnamoyl)-d-glucopyranose (2), along with nine known compounds (3–11) were isolated from the ethanol extract of Ginkgo biloba leaves. Their structures were elucidated by combination of spectroscopic analyses and alkaline methanolysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction. All the isolated compounds were evaluated for their cytotoxicity activities, and compound 11 exhibited IC50 values of 36.20 and 58.95 μM against 5637 and HeLa cell lines, respectively.
KeywordsGinkgo biloba Alkaline methanolysis X-ray diffraction Cytotoxicity
We are grateful to Lanxiang Dai for the collection of Ginkgo biloba leaves and Prof. Lin Yang at Lanzhou University of Technology for the authentication of the plant material. This work was financially supported by the National Natural Science Foundation of China (No. 21702178), Key Scientific Research Program in Universities of Henan Province (No. 18A350010), Science and Technology Project of Henan Province (No. 182102311108), and Excellent Young Key Teacher Funding Project of Xuchang University (No. 2017).
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