Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities
- 62 Downloads
A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1–4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism.
KeywordsCasearia kurzii Clerodane diterpenoids Cytotoxic activities Apoptosis Cell cycle
This work was supported by the National University Student Innovation Program of Nankai University, the National Natural Science Foundation of China (No. U1703107), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and Hundred Young Academic Leaders Program of Nankai University.
Compliance with ethical standards
Conflict of interest
The authors have declared no competing interests.
- 1.Editorial Committee of the Flora of China (1999) Flora of China. Science Press, Beijing, pp 69–71Google Scholar
- 4.dos Santos AG, Ferreira PM, Vieira Júnior GM, Perez CC, Gomes Tininis A, Silva GH, Bolzani Vda S, Costa-Lotufo LV, Pessoa Cdo O, Cavalheiro AJ (2010) Casearin X, its degradation product and other clerodane diterpenes from leaves of Casearia sylvestris: evaluation of cytotoxicity against normal and tumor human cells. Chem Biodivers 7:205–215CrossRefPubMedGoogle Scholar
- 16.Gao S, Sun D, Wang G, Zhang J, Jiang Y, Li G, Zhang K, Wang L, Huang J, Chen L (2016) Growth inhibitory effect of paratocarpin E, a prenylated chalcone isolated from Euphorbia humifusa Wild., by induction of autophagy and apoptosis in human breast cancer cells. Bioorg Chem 69:121–128CrossRefPubMedGoogle Scholar