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Four limonoids from the seeds extract of Sandoricum koetjape

  • Miranti B. Bumi
  • Leny Heliawaty
  • Elvira Hermawati
  • Yana M. SyahEmail author
Note
  • 51 Downloads

Abstract

Three andirobin- and one trijugin-class limonoids, named koetjapins A-D (14), have been isolated from the seed extracts of Sandoricum koetjape. The structures of these compounds were determined by extensive NMR and mass spectral data, and the chemotaxonomic significance of these limonoids in the family Meliaceae is highlighted. Preliminary biological activity showed that only compound 4 has significant inhibitory activity against P-388 cells, while antibacterial tests showed that none of these compounds were active.

Keywords

Koetjapins A-D Limonoid Andirobin Trijugin Sandoricum koetjape Meliaceae Cytotoxicity Antibacterial 

Notes

Acknowledgements

We acknowledge the Grant from Riset KK A 2018, Institut Teknologi Bandung, for financial support to this research.

Supplementary material

11418_2019_1303_MOESM1_ESM.cdx (63 kb)
Supplementary material 1 (CDX 64 kb)

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Copyright information

© The Japanese Society of Pharmacognosy 2019

Authors and Affiliations

  1. 1.Organic Chemistry DivisionBandung Institute of TechnologyBandungIndonesia
  2. 2.Department of Chemistry, Faculty of Mathematics and Natural SciencesUniversity of PakuanBogorIndonesia

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