Four limonoids from the seeds extract of Sandoricum koetjape
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Three andirobin- and one trijugin-class limonoids, named koetjapins A-D (1–4), have been isolated from the seed extracts of Sandoricum koetjape. The structures of these compounds were determined by extensive NMR and mass spectral data, and the chemotaxonomic significance of these limonoids in the family Meliaceae is highlighted. Preliminary biological activity showed that only compound 4 has significant inhibitory activity against P-388 cells, while antibacterial tests showed that none of these compounds were active.
KeywordsKoetjapins A-D Limonoid Andirobin Trijugin Sandoricum koetjape Meliaceae Cytotoxicity Antibacterial
We acknowledge the Grant from Riset KK A 2018, Institut Teknologi Bandung, for financial support to this research.
- 1.Muellner AN, Samuel R, Chase MW, Coleman A, Stuessy TF (2008) An evaluation of tribe and generic relationship in Melioideae (Meliaceae) based on nuclear ITS Ribosomal DNA. Taxon 57:98–108Google Scholar
- 3.King FE, Morgan JWW (1960) The chemistry of extractives from hardwoods. Part XXX. The constitution of katonic acid, a triterpene from Sandoricum indicum. J Chem Soc 0:4738–4747Google Scholar
- 18.Pennington TD, Styles BT (1975) A generic monograph of the Meliaceae. Blumea 22:419–540Google Scholar
- 20.Chiruvella KK, Mohammed A, Dampuri G, Ghanta RG, Raghavan SC (2007) Phytochemical and antimicrobial studies of methyl angolensate and luteolin-7-O-glucoside isolated from callus cultures of Soymida febrifuga. Int J Biomed Sci 3:269–278Google Scholar
- 22.Windayani N, Juliawaty LD, Hakim EH, Ruslan K, Syah YM (2015) An acetylated triterpene glycoside and lignans from Phyllanthus myrtifolius and their antibacterial activities. Nat Prod J 5:152–157Google Scholar