Journal of Natural Medicines

, Volume 73, Issue 1, pp 146–153 | Cite as

Bioactive constituents obtained from the fruits of Citrus aurantium

  • Yi Zhang
  • Peijian Huang
  • Wei He
  • Kaunda Joseph Sakah
  • Jingya Ruan
  • Zheng Li
  • Tao WangEmail author
Original Paper


Three new compounds, citrusauranosides A (1), B (2), and C (3), along with 22 known compounds (425) were obtained from the 70% ethanol–water extract of the fruits of Citrus aurantium L.. Their structures were identified by spectroscopic methods. Among the known compounds, 14, 15, 17 and 23 were firstly obtained from Citrus genus, and the NMR data of 17 is reported here for the first time. Moreover, inhibitory effects of all compounds on motility of mouse isolated intestine tissue were determined. As a result, 1, 48, and 11 displayed significant inhibitory effects on contraction tension.


Citrus aurantium L. Chemical constituents Intestine motility Mouse isolated intestine tissue 



Part of this research was supported by Programs for National Natural Science Foundation of China (81673688).

Supplementary material

11418_2018_1255_MOESM1_ESM.doc (1.3 mb)
Supplementary material 1 (DOC 1309 kb)


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Yi Zhang
    • 1
  • Peijian Huang
    • 2
  • Wei He
    • 2
  • Kaunda Joseph Sakah
    • 1
  • Jingya Ruan
    • 1
  • Zheng Li
    • 1
  • Tao Wang
    • 1
    • 2
    Email author
  1. 1.Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjinChina
  2. 2.Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjinChina

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