New depsidone and dichromone from the stems of Garcinia paucinervis with antiproliferative activity
- 94 Downloads
A new depsidone, paucinervin Q (1), a new dichromone, paucinervin R (2), and a known compound, paucinervin B (3), were isolated from the stems of Garcinia paucinervis by various chromatographic methods. Their structures were determined by analysis of spectroscopic data. The isolates were evaluated for their antiproliferative activity against three cancer cell lines HL-60, PC-3 and CaCo-2. Compound 1 showed significant inhibitory activities.
KeywordsGarcinia paucinervis Depsidone Dichromone Cytotoxicity
This study was financially supported by the National Natural Science Foundation of China (31570350), and the key laboratory basic research projects of Department of Education in Liaoning Province (LZ2014044).
Compliance with ethical standards
Conflict of interest
There are no conflicts to declare.
- 3.Liu B, Zhang XB, Bussmann RW, Hart RH, Li P, Bai YJ, Long CL (2017) Garcinia in southern China: ethnobotany, management, and niche modeling. Econ Bot 70:417–430Google Scholar
- 6.Li P, Yue GGL, Kwok HF, Long CL, Lau CBS, Kennelly EJ (2017) Using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometrics for the identification of anti-angiogenic biflavonoids from edible Garcinia species. J Agric Food Chem 65:8348–8355CrossRefGoogle Scholar
- 23.Fan QF, Na Z, Hu HB, Xu YK, Tang T (2012) Chemical constituents from stem barks of Garcinia paucinervis. Chin Tradit Herb Drugs 43:436–439Google Scholar