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Journal of Natural Medicines

, Volume 73, Issue 1, pp 252–256 | Cite as

Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities

  • Wenwen PengEmail author
  • Guanghu Huo
  • Lixia Zheng
  • Zhonghua Xiong
  • Xugen Shi
  • Dayong Peng
Note
  • 91 Downloads

Abstract

Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (35) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC50 values ranging from 6.97 to 18.13 μM.

Keywords

Leonurus japonicus Oleanane triterpenes Cytotoxic activities A549 HeLa 

Notes

Acknowledgements

This work was financially supported by the Funds of NSFC-Jiangxi Province (No. 20161BAB204179), Jiangxi provincial education office (No. GJJ150407), and Post Doctoral in Jiangxi (No. 06292023).

Compliance with ethical standards

Conflict of interest

The authors indicate that there is no conflict of interest.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Wenwen Peng
    • 1
    • 2
    • 3
    Email author
  • Guanghu Huo
    • 1
  • Lixia Zheng
    • 3
  • Zhonghua Xiong
    • 3
  • Xugen Shi
    • 3
  • Dayong Peng
    • 2
  1. 1.Jiangxi Key Laboratory for Conservation and Utilization of Fungal ResourcesJiangxi Agricultural UniversityNanchangChina
  2. 2.Jiangxi Key Laboratory of Natural Products and Functional FoodJiangxi Agricultural UniversityNanchangChina
  3. 3.College of AgricultureJiangxi Agricultural UniversityNanchangChina

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