Two flavonol glycosides from Liparis bootanensis
- 231 Downloads
Two new flavonol glycosides, bootanenside I and II (1 and 2), along with ten known compounds (3–12), were isolated from whole plant of Liparis bootanensis Griff. Their structures were elucidated on the basis of extensive spectroscopic analyses, including high-resolution electrospray-ionization mass spectrometry (HR–ESIMS) and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR). The cytotoxicity of the compounds was investigated against HCT116 human cancer cell line, revealing that none of them possessed considerable cytotoxic activity. Bioassays of the new metabolites showed that compounds 1 and 2 displayed moderate in vitro antiinflammatory activity by inhibiting expression of inducible nitric oxide synthase (iNOS) protein in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
KeywordsOrchidaceae Liparis bootanensis Griff. Flavonol glycosides Bootanensides Antiinflammatory
This research was supported by grants from the National Natural Science Foundation of China (81402803), project of Science and Technology Bureau of Chengdu (2015-HM01-00041-SF), and US National Institutes of Health (R01 HL128647 to C.L.).
Compliance with ethical standards
Conflict of interest
All the authors have no conflicts of interest to declare.
- 1.Chen SC, Ormerod P, Wood JJ (2009) Orchidaceae. In: Wu ZY, Raven PH, Hong DY (eds) Flora of China, Vol 25. Science Press, Beijing, and Missouri Botanical Garden Press, St., pp 211–228Google Scholar
- 8.Zhao Y, Hu S, Wang C, Zheng Y, Xu X (2013) Chemical constituents from Liparis nervosa. Chin Tradit Herb Drugs 44:2955–2959Google Scholar
- 10.Hua YX, Liu SF, Yang ZQ (1999) The Chinese herbal, vol 12. Shanghai Science and Technology Publishing House, Shanghai, p 997Google Scholar
- 11.Yang J, Wang L, Zhou X, Yuan J, Zhang T, Liu F (2014) Chemical constituents from Melilotus officinalis. Tradit Herb Drugs 45:622–625Google Scholar
- 12.Li Y, Zhou Y, Chen G, Pei Y, Qin X (2014) Isolation and identification of phenols from Cynanchum paniculatum. J Shenyang Pharm Univ 31:444–447Google Scholar
- 14.Reisch J, Bathory M, Novak I, Szendrei K (1970) Structure and biochemistry of natural phenanthrene derivatives. Herba Hung 9:43–48Google Scholar