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Journal of Natural Medicines

, Volume 72, Issue 2, pp 523–529 | Cite as

Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

  • Shinen Naranmandakh
  • Toshihiro MurataEmail author
  • Batsukh Odonbayar
  • Keisuke Suganuma
  • Javzan Batkhuu
  • Kenroh Sasaki
Original Paper

Abstract

Fomitopsis officinalis is a medicinal fungus, known as ‘Agarikon’, and is used traditionally in the treatment of asthma and rheumatism in Mongolia. The investigation of the chemical constituents of F. officinalis led to the isolation of 4 new lanostane triterpenoids together with 4 known triterpenoids. Inhibitory activity against Trypanosoma congolense, which causes fatal diseases in animals including livestock, was estimated for the isolated compounds. Compounds 25 and 8 exhibited moderate inhibition activities with IC50 values ranging from 7.0−27.1 µM.

Keywords

Fomitopsis officinalis Traditional medicinal mushroom Agarikon Lanostane triterpenoid Trypanosoma Mongolia 

Notes

Acknowledgements

We thank Ms. Y. Matsushita, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, for assistance with the trypanocidal activity experiments, and Mr. S. Sato and Mr. T. Matsuki, Tohoku Medical and Pharmaceutical University, for assistance with the MS measurements. This work was supported by JICA M-JEED project and a grant from JSPS Kakenhi (Grant Number JP26860068). This work was partially supported by an Advanced Research Grant from the National University of Mongolia, the Kanno Foundation of Japan, a Cooperative Research Grant (28-joint-12, 29-joint-6) from the National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, and AMED/JICA SATREPS.

Compliance with ethical standards

Conflict of interest

The authors indicate that there is no conflict of interest.

Supplementary material

11418_2018_1182_MOESM1_ESM.pdf (1.2 mb)
Supplementary material 1 (PDF 1200 kb)

References

  1. 1.
    Stamets PE (2014) Antiviral and antibacterial activity from medicinal mushrooms. US Patent 8,765,138 B2Google Scholar
  2. 2.
    Grienke U, Zöll M, Peintner U, Rollinger JM (2014) European medicinal polypores-a modern view on traditional uses. J Ethnopharmacol 154:564–583CrossRefGoogle Scholar
  3. 3.
    Wu X, Yang JS, Yan M (2009) Four new triterpenes from fungus of Fomes officinalis. Chem Pharm Bull 57:195–197CrossRefGoogle Scholar
  4. 4.
    Feng W, Yang JS (2015) A new drimane sesquiterpenoid and a new triterpene lactone from fungus of Fomes officinalis. J Asian Nat Prod Res 17:1065–1072CrossRefGoogle Scholar
  5. 5.
    Wu X, Yang JS, Zhou L, Dong YS (2004) New lanostane-type triterpenes from Fomes officinalis. Chem Pharm Bull 52:1375–1377CrossRefGoogle Scholar
  6. 6.
    Han JX, Li L, Zhong JL, Tohtaton Z, Ren Q, Han L, Huang X, Yuan T (2016) Officimalonic acids A-H, lanostane triterpenes from the fruiting bodies of Fomes officinalis. Phytochemistry 130:193–200CrossRefGoogle Scholar
  7. 7.
    Anderson CG, Epstein WW, Van Lear G (1972) Minor triterpenoids of Fomes officinalis. Phytochemistry 11:2847–2852CrossRefGoogle Scholar
  8. 8.
    Epstein WW, Sweat FW, VanLear G, Lovell FM, Gabe EJ (1979) Structure and stereochemistry of officinalic acid, a novel triterpene from Fomes officinalis. J Am Chem Soc 101:2748–2750CrossRefGoogle Scholar
  9. 9.
    Anderson CG, Epstein WW (1971) Metabolic intermediates in the biological oxidation of lanosterol to eburicoic acid. Phytochemistry 10:2713–2717CrossRefGoogle Scholar
  10. 10.
    Hwang CH, Jaki BU, Klein LL, Lankin DC, McAlpine JB, Napolitano JG, Fryling NA, Franzblau SG, Cho SH, Stamets PE, Wang YH, Pauli GF (2013) Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. J Nat Prod 76:1916–1922CrossRefGoogle Scholar
  11. 11.
    Naranmandakh Sh, Bayarmaa E, Undarmaa B, Brantner AH (2010) Antibacterial active compounds of the fungus Fomitopsis officinalis (Vill. ex Fr; Bond. et Singer). Annual Scientific Reports, vol 11. ICCT, Mongolian Academy of Sciences, Ulaanbaatar, pp 67–71Google Scholar
  12. 12.
    Banzragchgarav O, Murata T, Odontuya G, Buyankhishig B, Suganuma K, Davaapurev B, Inoue N, Batkhuu J, Sasaki K (2016) Trypanocidal activity of 2,5-diphenyloxazoles isolated from the roots of Oxytropis lanata. J Nat Prod 79:2933–2940CrossRefGoogle Scholar
  13. 13.
    Isaka M, Chinthanom P, Srichomthong K, Thummarukcharoen T (2017) Lanostane triterpenoids from fruiting bodies of the bracket fungus Fomitopsis feei. Tetrahedron Lett 58:1758–1761CrossRefGoogle Scholar
  14. 14.
    Kamo T, Asanoma M, Shibata H, Hirota M (2003) Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus. J Nat Prod 66:1104–1106CrossRefGoogle Scholar
  15. 15.
    Quang DN, Arakawa Y, Hashimoto T, Asakawa Y (2005) Lanostane triterpenoids from the inedible mushroom Fomitopsis spraguei. Phytochemistry 66:1656–1661CrossRefGoogle Scholar
  16. 16.
    Hoet S, Pieters L, Muccioli GG, Habib-Jiwan JL, Opperdoes FR, Quetin-Leclercq J (2007) Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. J Nat Prod 70:1360–1363CrossRefGoogle Scholar
  17. 17.
    Umeyama A, Ohta C, Shino Y, Okada M, Nakamura Y, Hamagaki T, Imagawa H, Tanaka M, Ishiyama A, Iwatsuki M, Otoguro K, Ōmura S, Hashimoto T (2014) Three lanostane triterpenoids with antitrypanosomal activity from the fruiting body of Hexagonia tenuis. Tetrahedron 70:8312–8315CrossRefGoogle Scholar
  18. 18.
    Suganuma K, Allamanda P, Hakimi H, Zhou M, Angeles JM, Kawazu S, Inoue N (2014) Establishment of ATP-based luciferase viability assay in 96-well plate for Trypanosoma congolense. J Vet Med Sci 76:1437–1441CrossRefGoogle Scholar
  19. 19.
    Hirumi H, Hirumi K (1991) In vitro cultivation of Trypanosoma congolense bloodstream forms in the absence of feeder cell layers. Parasitology 102:225–236CrossRefGoogle Scholar

Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Arts and SciencesNational University of MongoliaUlaanbaatarMongolia
  2. 2.Department of PharmacognosyTohoku Medical and Pharmaceutical UniversitySendaiJapan
  3. 3.Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary MedicineObihiroJapan
  4. 4.School of Engineering and Applied SciencesNational University of MongoliaUlaanbaatarMongolia

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