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Journal of Natural Medicines

, Volume 72, Issue 2, pp 570–575 | Cite as

Terpenoids from Vitex trifolia and their anti-inflammatory activities

  • Fengyan Bao
  • Ruotian Tang
  • Li Cheng
  • Cuiyun Zhang
  • Chongyue Qiu
  • Ting Yuan
  • Lihan Zhu
  • Hua LiEmail author
  • Lixia ChenEmail author
Note

Abstract

A new diterpenoid glucoside, (3S,5S,6S,8R,9R,10S)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-O-β-D-glucopyranoside (1), and a new iridoid glucoside, (1S, 5S,6R,9R)-10-O-p-hydroxybenzoyl-5,6β-dihydroxy iridoid 1-O-β-D-glucopyranoside (2), along with six known compounds (3-8) were isolated from Vitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds 2, 4, 5, and 7 showed moderate inhibitory activities with IC50 values of 90.05, 88.51, 87.26, and 76.06 μM, respectively.

Keywords

Vitex trifolia L. Diterpenoid Iridoid Anti-inflammatory effect 

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Fengyan Bao
    • 1
  • Ruotian Tang
    • 2
  • Li Cheng
    • 1
  • Cuiyun Zhang
    • 1
  • Chongyue Qiu
    • 1
  • Ting Yuan
    • 1
  • Lihan Zhu
    • 1
  • Hua Li
    • 1
    • 2
    Email author
  • Lixia Chen
    • 1
    Email author
  1. 1.Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of EducationShenyang Pharmaceutical UniversityShenyangChina
  2. 2.Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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