Journal of Natural Medicines

, Volume 72, Issue 2, pp 551–556 | Cite as

Structure–activity relationships of flavanones, flavanone glycosides, and flavones in anti-degranulation activity in rat basophilic leukemia RBL-2H3 cells

  • Toshiro NoshitaEmail author
  • Kaori Miura
  • Kaoru Ikeda
  • Hidekazu Ouchi
  • Takuya Matsumoto
  • Akihiro TaiEmail author


The incidence of type I allergies, which are associated with mast cell degranulation and local inflammation, is increasing, and new treatments are needed. To date, structure–activity relationships of flavonoids in their degranulation-inhibiting activity have not been systematically characterized. In the current study, the degranulation-inhibiting activity of a series of flavonoids was evaluated. The following three observations were made: (1) the activity disappears when a sugar moiety is introduced into the A ring of the flavanone; (2) the activity depends on the number of hydroxyl groups on the B ring; (3) the activity is markedly enhanced when a double bond is introduced into the C ring. The information obtained in the current study may guide the development of a therapy for type I allergies.


Flavonoids Anti-degranulation Type I allergy Structure–activity relationship Rat basophilic leukemia RBL-2H3 cell 



The authors would like to thank Editage ( for English language editing.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Life Sciences, Faculty of Life and Environmental SciencesPrefectural University of HiroshimaShobaraJapan
  2. 2.Program in Biological System Sciences, Graduate School of Comprehensive Scientific ResearchPrefectural University of HiroshimaShobaraJapan
  3. 3.Department of Pharmacy, Faculty of PharmacyKindai UniversityHigashiosakaJapan
  4. 4.Department of Environmental Sciences, Faculty of Life and Environmental SciencesPrefectural University of HiroshimaShobaraJapan

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