New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1
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Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.
KeywordsNigella damascena Ranunculaceae Diterpene Antiviral activity HSV-1
This research was supported in part by a Ministry of Education, Culture, Sports, Science and Technology (MEXT)-Supported Program for the Strategic Research Foundation at Private Universities 2015–2019.
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