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Journal of Natural Medicines

, Volume 72, Issue 1, pp 347–356 | Cite as

New 8,12;8,20-diepoxy-8,14-secopregnane hexa- and hepta-glycosides from the roots of Asclepias tuberosa

  • Tsutomu WarashinaEmail author
  • Toshio Miyase
Note

Abstract

Previously, phytochemical investigation of the roots of Asclepias tuberosa (Asclepiadaceae) led to the isolation of some 8,12;8,20-diepoxy-8,14-secopregnane tri-, tetra-, and penta-glycosides. An additional eight new minor 8,12;8,20-diepoxy-8,14-secopregnane glycosides were afforded in the recent investigation of this plant. These glycosides consisted of six or seven 2,6-dideoxy-hexopyranoses together with the aglycone, tuberogenin. The structures of each of these compounds were established using NMR, mass spectroscopic analysis and chemical evidence. As 8,12;8,20-diepoxy-8,14-secopregnane-type glycosides were observed only in A. tuberosa, these compounds were considered to be characteristic phytochemicals of this plant.

Keywords

Asclepias tuberosa Asclepiadaceae 8,12;8,20-diepoxy-8,14-seco-pregnane glycoside Tuberoside 

Notes

Compliance with ethical standards

Conflict of interest

No potential conflict of interest was reported by the authors.

Supplementary material

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Supplementary material 1 (DOC 1142 kb)
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Supplementary material 4 (DOC 59 kb)

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2017

Authors and Affiliations

  1. 1.School of Food and Nutritional SciencesUniversity of ShizuokaShizuokaJapan
  2. 2.School of Pharmaceutical SciencesUniversity of ShizuokaShizuokaJapan

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