Journal of Natural Medicines

, Volume 72, Issue 1, pp 12–19 | Cite as

Biological activity of Entada phaseoloides and Entada rheedei

  • Sachiko Sugimoto
  • Katsuyoshi Matsunami
  • Hideaki OtsukaEmail author
Review In memoriam to Professor Shoji Shibata: Pioneer in Modern Pharmacognosy


The aim of our study is to find functional compounds from natural resources. We focus on plants grown in tropical areas, especially Madagascar and Thailand, because they have unique flora and are expected to contain interesting compounds. We review the functional compounds of the seed kernels of Entada phaseoloides and E. rheedei and their biological activities such as anti-proliferation and melanogenesis inhibitory properties, etc.


Entada phaseoloides Entada rheedei Anti-proliferation Entadoside Rheedeioside Entadamide 



The authors are grateful for access to the superconducting NMR instrument (JEOL JNM-LA500 and ECA-600K) and the Thermo Fisher Scientific LTQ Orbitrap XL mass spectrometer at the Natural Science Center for Basic Research and Development, Hiroshima University. This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and the Japan Society for the Promotion of Science. Thanks are also due to the Takeda Science Foundation for financial support.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK 2017

Authors and Affiliations

  • Sachiko Sugimoto
    • 1
  • Katsuyoshi Matsunami
    • 1
  • Hideaki Otsuka
    • 2
    Email author
  1. 1.Department of Pharmacognosy, Graduate School of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Faculty of PharmacyYasuda Women’s UniversityHiroshimaJapan

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