Journal of Natural Medicines

, Volume 72, Issue 1, pp 246–251 | Cite as

New phenanthrene and 9, 10-dihydrophenanthrene derivatives from the stems of Dendrobium officinale with their cytotoxic activities

  • Gui-Yun Zhao
  • Bo-Wen Deng
  • Chong-Yu Zhang
  • Yi-Da Cui
  • Jia-Yi Bi
  • Guo-Gang ZhangEmail author
Original Paper


Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1–2) with six known congeners (3–8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit through a dioxane bridge, respectively. Their structures were determined by comprehensive NMR spectroscopic data, the absolute configuration of new compounds were determined by comparing their experimental and calculated ECD for the first time. All the compounds were investigated contains two cancer cell lines (HI-60, THP-1). All the isolates showed cytotoxicity, especially compound 4 showed markedly cytotoxic activities against HI-60 and THP-1 cell lines with IC50 values of 11.96 and 8.92 μM.


Dendrobium officinale Phenanthrene derivative 9,10-dihydrophenanthrene Derivative Cytotoxicity 



We are appreciative of the Testing and Analysis Center of Shenyang Pharmaceutical University for the NMR measurements.

Supplementary material

11418_2017_1141_MOESM1_ESM.docx (6.3 mb)
Supplementary material 1 (DOCX 6448 kb)


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK 2017

Authors and Affiliations

  • Gui-Yun Zhao
    • 1
  • Bo-Wen Deng
    • 1
  • Chong-Yu Zhang
    • 1
  • Yi-Da Cui
    • 1
  • Jia-Yi Bi
    • 1
  • Guo-Gang Zhang
    • 1
    Email author
  1. 1.School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyangPeople’s Republic of China

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