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Journal of Natural Medicines

, Volume 72, Issue 1, pp 304–309 | Cite as

Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan

  • Nenling ZhangEmail author
  • Xiangchun Shen
  • Xiaofei Jiang
  • Jiazhong Cai
  • Xiaoling Shen
  • Yingjie Hu
  • Samuel X. Qiu
Note

Abstract

Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI–MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluated in vitro. Compound 1 showed strong cytotoxicity against all the tested cell lines (IC50 values: 2.14–2.56 µM), whereas compound 2 showed strong toxicity only against HepG2 (IC50 value: 5.99 µM) and A549 cells (IC50 value: 6.18 µM).

Keywords

Pigeon pea Stilbene dimer Cyclobutane Cytotoxicity 

Notes

Acknowledgements

This study was supported by the National Undergraduate Training Programs for Innovation and Entrepreneurship (No. 201610660024), Project of Health and Family Planning Committee of Guizhou Province (No. gzwjkj2014-2-103), Joint Fund of the Department of Science and Technology of Guizhou Province and Guizhou Medical University (No. LH [2015]7339), and Fund of the Innovation Team of Guizhou Province (No. 2015-4025).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11418_2017_1138_MOESM1_ESM.doc (903 kb)
Supplementary material 1 (DOC 903 kb)

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK 2017

Authors and Affiliations

  1. 1.Pharmacy College of Guizhou Medical UniversityGuiyangChina
  2. 2.Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical GardenChinese Academy of SciencesGuangzhouChina
  3. 3.Guangzhou University of Chinese MedicineGuangzhouChina

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