Journal of Natural Medicines

, Volume 72, Issue 1, pp 326–331 | Cite as

New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum

  • Toshihiro NoharaEmail author
  • Masateru Ono
  • Naho Nishioka
  • Fuka Masuda
  • Yukio Fujiwara
  • Tsuyoshi Ikeda
  • Daisuke Nakano
  • Junei Kinjo


One atypical thiolane-type sulfide, garlicnin I2 (1), two 3,4-dimethylthiolane-type sulfides, garlicnins M (2) and N (3), and one thiabicyclic-type sulfide, garlicnin O (4), were isolated from the acetone extracts of Chinese garlic bulbs, Allium sativum and their structures were characterized. Hypothetical pathways for the production of the respective sulfides were discussed.


Allium sativum Atypical thiolane-type 3,4-Dimethylthiolane-type Thiabicyclic-type Garlicnin M Garlicnin O 


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK 2017

Authors and Affiliations

  • Toshihiro Nohara
    • 1
    Email author
  • Masateru Ono
    • 2
  • Naho Nishioka
    • 2
  • Fuka Masuda
    • 2
  • Yukio Fujiwara
    • 3
  • Tsuyoshi Ikeda
    • 1
  • Daisuke Nakano
    • 4
  • Junei Kinjo
    • 4
  1. 1.Faculty of Pharmaceutical SciencesSojo UniversityKumamotoJapan
  2. 2.School of AgricultureTokai UniversityKumamotoJapan
  3. 3.Graduate School of Medical Sciences, Faculty of Life SciencesKumamoto UniversityKumamotoJapan
  4. 4.Faculty of Pharmaceutical SciencesFukuoka UniversityFukuokaJapan

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