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Journal of Natural Medicines

, Volume 72, Issue 1, pp 166–180 | Cite as

C21 steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activity

  • Xu Pang
  • Li-Ping Kang
  • Xiao-Mei Fang
  • He-Shui Yu
  • Li-Feng Han
  • Yang Zhao
  • Li-Xia Zhang
  • Li-Yan Yu
  • Bai-Ping MaEmail author
Original Paper

Abstract

Twenty-three new C21 steroidal glycosides, marstenacissides C1–C10 (110), D1–D7 (1117) and E1–E6 (1823), and four new C21 steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), were isolated from the Dai herbal medicine Dai-Bai-Jie, derived from the roots of Marsdenia tenacissima. The chemical structures of all compounds were established by spectroscopic techniques, including high-resolution mass spectrometry and NMR spectroscopy, as well as by comparison with reported spectral data. The anti-HIV activities of these compounds were screened, and the compounds obtained displayed inhibitory effects against HIV-1 with inhibition rates of 36.4–81.3% at 30 μM.

Keywords

Marsdenia tenacissima Asclepiadaceae Marstenacisside C21 steroid Anti-HIV 

Notes

Acknowledgement

Thanks to Miss Meifeng Xu in National Center of Biomedical Analysis (NCBA) for the measurements of the NMR spectra.

Compliance with ethical standards

Conflict of interests

There are no conflicts of interests of all authors.

Supplementary material

11418_2017_1126_MOESM1_ESM.pdf (11.3 mb)
Supplementary material 1 (PDF 11614 kb)

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK 2017

Authors and Affiliations

  • Xu Pang
    • 1
    • 2
  • Li-Ping Kang
    • 1
    • 2
  • Xiao-Mei Fang
    • 3
  • He-Shui Yu
    • 2
  • Li-Feng Han
    • 2
  • Yang Zhao
    • 1
  • Li-Xia Zhang
    • 4
  • Li-Yan Yu
    • 3
  • Bai-Ping Ma
    • 1
    Email author
  1. 1.Beijing Institute of Radiation MedicineBeijingChina
  2. 2.Tianjin University of Traditional Chinese MedicineTianjinChina
  3. 3.Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  4. 4.Yunnan Branch of Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeJinghongChina

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