Journal of Natural Medicines

, Volume 71, Issue 1, pp 310–314 | Cite as

Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina

  • Sutin Kaennakam
  • Pongpun Siripong
  • Santi Tip-pyang
Note

Abstract

Two new isoflavanes, dalvelutinanes A (1) and B (2), along with three known isoflavanes (35) were isolated from the roots of Dalbergia velutina. Their chemical structures, including their absolute configurations, were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS, and CD). All isolated compounds were evaluated for their in vitro cytotoxicities against five human cancer cell lines (KB, HeLa-S3, MCF-7, HepG-2, and HT-29). Compound 5 showed significant cytotoxicity against all of the tested cancer cell lines, with IC50 values in the range 3.47–9.76 µM. In addition, compound 3 showed significant cytotoxicity against the KB and HeLa-S3 cells, with IC50 values of 8.29 and 9.54 µM, respectively, and compound 2 showed significant cytotoxicity against the MCF-7 cell line, with an IC50 value of 4.69 µM.

Keywords

Dalbergia velutina Dalvelutinanes A and B Isoflavanes Cytotoxicity 

Notes

Acknowledgments

The authors are grateful to the Graduate School of Chulalongkorn University for a postdoctoral fellowship (Ratchadaphiseksomphot Endowment Fund) to S.K. We also thank Dr. Suttira Khumkratok, Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand for the identification and deposition of the plant material.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  • Sutin Kaennakam
    • 1
  • Pongpun Siripong
    • 2
  • Santi Tip-pyang
    • 1
  1. 1.Natural Products Research Unit, Department of Chemistry, Faculty of ScienceChulalongkorn UniversityBangkokThailand
  2. 2.Natural Products Research Section, Research DivisionNational Cancer InstituteBangkokThailand

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