pp 1–15 | Cite as

Ellagic acid prolongs the lifespan of Drosophila melanogaster

  • Priyanka Kharat
  • Priyanka Sarkar
  • S. Mouliganesh
  • Vaibhav Tiwary
  • V.B. Ramya Priya
  • N. Yamini Sree
  • H. Vinu Annapoorna
  • Diganta K. Saikia
  • Kaustav Mahanta
  • Kavitha ThirumuruganEmail author
Original Article


Wild-type Canton-S flies of Drosophila melanogaster were treated with ellagic acid at 100 μM and 200 μM concentrations. Longevity assay showed male flies fed with 200 μM ellagic acid displayed longer mean lifespan and maximum lifespan than control flies. Female flies fed with 200 μM ellagic acid laid less number of eggs than control. The eclosion time was less in female flies fed with 200 μM ellagic acid. Ellagic acid fed female flies performed better than male flies and control flies for heat shock tolerance and starvation stress. Male flies treated with 100 μM ellagic acid recovered faster from cold shock compared with control flies. Male and female flies treated with ellagic acid displayed increased survival following exposure to 5% hydrogen peroxide. Gene expression studies displayed upregulated expressions of CAT, dFOXO, ATG1, and SOD2 in ellagic acid–treated male flies, and upregulated expressions of dFOXO, CAT, and SOD2 in ellagic acid–treated female flies. Results from these studies show the pro-longevity effect of ellagic acid on Drosophila melanogaster.


Ellagic acid Drosophila melanogaster Longevity Stress Gene expression 



We thank Dr. N.B. Ramachandra at Mysore University, National Drosophila Stock Centre, India, for providing the wild-type Canton-S fly strain. We are thankful to Vellore Institute of Technology for the seed grant and facilities provided.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11357_2019_135_MOESM1_ESM.docx (630 kb)
ESM 1 (DOCX 630 kb)
11357_2019_135_MOESM2_ESM.docx (25 kb)
ESM 2 (DOCX 25.1 kb)


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Copyright information

© American Aging Association 2019

Authors and Affiliations

  • Priyanka Kharat
    • 1
  • Priyanka Sarkar
    • 1
  • S. Mouliganesh
    • 1
  • Vaibhav Tiwary
    • 1
  • V.B. Ramya Priya
    • 1
  • N. Yamini Sree
    • 1
  • H. Vinu Annapoorna
    • 1
  • Diganta K. Saikia
    • 1
  • Kaustav Mahanta
    • 1
  • Kavitha Thirumurugan
    • 1
    Email author
  1. 1.206, Structural Biology Laboratory, Centre for Biomedical Research, School of Biosciences & TechnologyVellore Institute of TechnologyVelloreIndia

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