Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice
The incidence of neurodegenerative disorders and cognitive impairment is increasing. Rising prevalence of age-related medical conditions is associated with a dramatic economic burden; therefore, developing strategies to manage these health concerns is of great public health interest. Nutritionally based interventions have shown promise in treatment of these age-associated conditions. Astaxanthin is a carotenoid with reputed neuroprotective properties in the context of disease and injury, while emerging evidence suggests that astaxanthin may also have additional biological activities relating to neurogenesis and synaptic plasticity. Here, we investigate the potential for astaxanthin to modulate cognitive function and neural plasticity in young and aged mice. We show that feeding astaxanthin to aged mice for 1 month improves performance on several hippocampal-dependent cognitive tasks and increases long-term potentiation. However, we did not observe an alteration in neurogenesis, nor did we observe a change in microglial-associated IBA1 immunostaining. This demonstrates the potential for astaxanthin to modulate neural plasticity and cognitive function in aging.
KeywordsAging Cognitive decline Inflammation Nutraceutical Neuroplasticity
Brain-derived neurotrophic factor
Field excitatory post synaptic potentials
Neural progenitor cell
Ionized calcium-binding adaptor protein
Funding was provided from the NIA R01 AG044919 (PCB) and the Veterans Administration I01 BX003421 (PCB).
Compliance with ethical standards
The contents of this presentation do not represent the views of the Department of Veterans Affairs or the United States Government.
Conflict of interest
PCB is the co-Founder of Natura Therapeutics, Inc., and has served on the scientific advisory board for Nutrex Hawaii.
- Arvanitakis Z, Fleischman DA, Arfanakis K, Leurgans SE, Barnes LL, Bennett DA (2016) Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment. Brain Struct Funct 221:2135–2146. https://doi.org/10.1007/s00429-015-1034-7 Google Scholar
- Gite S, Ross RP, Kirke D, Guihéneuf F, Aussant J, Stengel DB, Dinan TG, Cryan JF, Stanton C (2018) Nutraceuticals to promote neuronal plasticity in response to corticosterone-induced stress in human neuroblastoma cells. Nutr Neurosci:1–18. https://doi.org/10.1080/1028415X.2017.1418728
- Grimmig BA, Daly L, Hudson C, Nash K, Bickford PC (2017) Astaxanthin attenuates neurotoxicity in a mouse model of PD. Funct Foods Health Dis 7:562–567Google Scholar
- Kidd P (2011) Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev 16:355–364Google Scholar
- Kim B, Farruggia C, Ku CS, Pham TX, Yang Y, Bae M, Wegner CJ, Farrell NJ, Harness E, Park YK, Koo SI, Lee JY (2016) Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis. J Nutr Biochem 43:27–35. https://doi.org/10.1016/j.jnutbio.2016.01.006 Google Scholar
- Qiao J, Rong L, Wang Z, Zhang M (2017) Involvement of Akt/GSK3beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment. Neurosci Lett 649:55–61. https://doi.org/10.1016/j.neulet.2017.03.048 Google Scholar
- Velkoff GVaV (2010) The next four decades The older population in the United States: 2010 to 2050 Current population reportsGoogle Scholar
- Wang HQ, Sun XB, Xu YX, Zhao H, Zhu QY, Zhu CQ (2010) Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Res 1360:159–167. https://doi.org/10.1016/j.brainres.2010.08.100 Google Scholar
- Xu L, Zhu J, Yin W, Ding X (2015) Astaxanthin improves cognitive deficits from oxidative stress, nitric oxide synthase and inflammation through upregulation of PI3K/Akt in diabetes rat. Int J Clin Exp Pathol 8:6083–6094Google Scholar
- Yamashita E (2013) Astaxanthin as a medical food. Funct Foods Health Dis 3:254–258Google Scholar
- Zhang XS, Zhang X, Zhou ML, Zhou XM, Li N, Li W, Cong ZX, Sun Q, Zhuang Z, Wang CX, Shi JX (2014) Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage. J Neurosurg 121:42–54. https://doi.org/10.3171/2014.2.jns13730 Google Scholar