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Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases

  • Priya Balasubramanian
  • Delton Hall
  • Madhan Subramanian
Review Article
  • 24 Downloads

Abstract

Chronic sympathetic nervous system overactivity is a hallmark of aging and obesity and contributes to the development of cardiovascular diseases including hypertension and heart failure. The cause of this chronic sympathoexcitation in aging and obesity is multifactorial and centrally mediated. In this mini-review, we have provided an overview of the key and emerging central mechanisms contributing to the pathogenesis of sympathoexcitation in obesity and healthy aging, specifically focusing on hypertension. A clear understanding of these mechanisms will pave way for targeting the sympathetic nervous system for the treatment of cardiovascular diseases in obesity and aging.

Keywords

Obesity Aging Hypertension Sympathetic nerve activity Inflammation Leptin Renin-angiotensin system Oxidative stress Cellular senescence 

Notes

Funding information

This work was supported by RAC fund to MS from the Center for Veterinary Health Sciences, Oklahoma State University.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© American Aging Association 2018

Authors and Affiliations

  1. 1.Reynolds Oklahoma Center on AgingUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  2. 2.Department of Physiological Sciences, Center for Veterinary Health SciencesOklahoma State UniversityStillwaterUSA

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