Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases
Abstract
Chronic sympathetic nervous system overactivity is a hallmark of aging and obesity and contributes to the development of cardiovascular diseases including hypertension and heart failure. The cause of this chronic sympathoexcitation in aging and obesity is multifactorial and centrally mediated. In this mini-review, we have provided an overview of the key and emerging central mechanisms contributing to the pathogenesis of sympathoexcitation in obesity and healthy aging, specifically focusing on hypertension. A clear understanding of these mechanisms will pave way for targeting the sympathetic nervous system for the treatment of cardiovascular diseases in obesity and aging.
Keywords
Obesity Aging Hypertension Sympathetic nerve activity Inflammation Leptin Renin-angiotensin system Oxidative stress Cellular senescenceNotes
Funding information
This work was supported by RAC fund to MS from the Center for Veterinary Health Sciences, Oklahoma State University.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
References
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