The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China
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Diabetes mellitus (DM) is a common chronic disease worldwide. Ambient air pollution has long been proven to be associated with type 2 diabetes mellitus (T2DM) progression, but the underlying mechanism is not clear yet. In addition, previous studies mainly focused on the prevention of healthy people against the incidence of T2DM. We designed a panel study including two follow-ups and enrolled 39 patients with T2DM living in Beijing. Linear mixed model was fitted to assess the association between two pairs of variables (ambient air pollution exposure and C3 levels, ambient air pollution exposures and T2DM index). Mediation analysis of C3 between ambient air pollution exposure and indicators of T2DM progression was conducted. We found that PM2.5 exposures is are negatively associated with serum complement C3. Given that C3 might act as a protector of pancreas β cell, PM2.5 exposures could accelerate disease in T2DM populations. No mediation effects were found. This study reveals that exposures to PM2.5 can cause progression of diseases among T2DM populations.
KeywordsDiabetes mellitus T2DM population PM2.5 C3 Mediation effects
This study was supported by the China Medical Board (Grant No. 15-230); the Gong-Yi Program of Chinese Ministry of Environmental Protection (Grant No. 200909016); The Chinese Academy of Medical Science Innovation Fund for Medical Sciences (Grant No. 2017-I2M-1-009); National Natural Science Foundation of China (Grant No. 41771435); China Scholarship Council (Grant No. 201704910297); and the Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences (Grant No. Y88Q0300YD).
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Conflict of interest
The authors declare that they have no conflict of interest.
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