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A cohort study of banana plantation workers in the French West Indies: first mortality analysis (2000–2015)

  • Danièle LuceEmail author
  • Julien Dugas
  • Amandine Vaidie
  • Léah Michineau
  • Mounia El-Yamani
  • Luc Multigner
Environmental and human health issues related to long term contamination by chlordecone in the French West Indies

Abstract

Chlordecone, an organochlorine insecticide, was widely used in the French West Indies banana plantations. We set up a cohort of banana plantation workers who worked between 1973 and 1993, the period of authorized use of chlordecone. Vital status and causes of death were collected from French national registries. Workers were followed up from 1 January 2000 to 31 December 2015. Cause-specific mortality in the cohort was compared to that of the general population of the French West Indies by computing standardized mortality ratios (SMRs). A total of 11,112 workers (149,526 person-years, 77% men) were included in the mortality analysis, and 3647 deaths occurred over the study period. There was a slight deficit in all-cause mortality, which was statistically significant in men (SMR = 0.93, 95% CI 0.89–0.96), but not in women (SMR = 0.96, 95% CI 0.89–1.04). All-cancer mortality did not differ significantly from that of the general population (men: SMR = 0.96, 95% CI 0.90–1.03; women: SMR = 1.04, 95% CI 0.89–1.21). Significant excesses of deaths were observed for stomach cancer in women (SMR = 1.94, 95% CI 1.24–2.89) and pancreatic cancer in women farm owners (SMR = 2.31, 95% CI 1.06–4.39). Mortality from prostate cancer was similar to that of the general population in the whole cohort (SMR = 1.00; 95% CI 0.89–1.13) and non-significantly elevated among farm workers (SMR = 1.10, 95% CI 0.87–1.36). Non-significant increases in mortality were also observed for lung cancer in women, leukemia in men, and non-Hodgkin lymphoma in both genders.

Keywords

Banana plantations French West Indies Occupational cohort Mortality Standardized mortality ratio (SMR) Pesticides 

Notes

Acknowledgments

We are grateful to the General Social Security Funds (Caisses Générales de Sécurité Sociale) of Guadeloupe and Martinique for their collaboration. We thank Marie Barrau, Alexandra Doens, Sylvia Janky, Vanessa Jupiter, Jessica Obertan, Stéphane Renaud, and Nathalie Surville-Barland for their help in data collection.

Compliance with ethical standards

The study was approved by the Institutional Review Board of the French National Institute of Health and Medical Research (IRB-INSERM, n° 15-193) and by the French Data Protection Authority (CNIL n° DR-215-200). Access to the nominative questionnaires of the agricultural censuses was authorized by the Committee on Statistical Confidentiality of the National Institute of Statistics and Economic Studies (session 14 January 2015, n° E270).

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11356_2019_6481_MOESM1_ESM.pdf (355 kb)
ESM 1 (PDF 355 kb)

References

  1. Acquavella J, Olsen G, Cole P, Ireland B, Kaneene J, Schuman S, Holden L (1998) Cancer among farmers: a meta-analysis. Ann Epidemiol 8:64–74CrossRefGoogle Scholar
  2. Agreste (1976) Recensement général de l’agriculture 1973. Service Central des Enquêtes et Etudes Statistiques. Ministère de l’Agriculture, ParisGoogle Scholar
  3. Agreste (1984) Service régional de statistique agricole des départements d’outre-mer, RGA 80-81. Inventaires par commune et zone agricole. Ministère de l'Agriculture, ParisGoogle Scholar
  4. Agreste (1990) Recensement agricole 1988-1989 – principaux résultats par commune et zone agricole. Ministère de l’Agriculture, ParisGoogle Scholar
  5. Alavanja MC, Dosemeci M, Samanic C, Lubin J, Lynch CF, Knott C, Barker J, Hoppin JA, Sandler DP, Coble J, Thomas K, Blair A (2004) Pesticides and lung cancer risk in the agricultural health study cohort. Am J Epidemiol 160:876–885CrossRefGoogle Scholar
  6. Alguacil J, Porta M, Benavides FG, Malats N, Kogevinas M, Fernandez E, Carrato A, Rifa J, Guarner L (2000) Occupation and pancreatic cancer in Spain: a case-control study based on job titles. PANKRAS II study group. Int J Epidemio 29:1004–1013CrossRefGoogle Scholar
  7. ASTDR, Agency for Toxic Substances and Disease Registry (2019) Toxicological profile for Mirex and chlordecone (draft for public comment). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. Available at: www.atsdr.cdc.gov/toxprofiledocs/index.html. Accessed 9 Jul 2019
  8. Blair A, Freeman LB (2009) Epidemiologic studies of cancer in agricultural populations: observations and future directions. J Agromed 14:125–131CrossRefGoogle Scholar
  9. Blair A, Zahm SH, Pearce NE, Heineman EF, Fraumeni JF Jr (1992) Clues to cancer etiology from studies of farmers. Scand J Work Environ Health 18:209–215CrossRefGoogle Scholar
  10. Blair A, Ritz B, Wesseling C, Freeman LB (2015) Pesticides and human health. Occup Environ Med 72:81–82CrossRefGoogle Scholar
  11. Bonner MR, Freeman LE, Hoppin JA, Koutros S, Sandler DP, Lynch CF, Hines CJ, Thomas K, Blair A, Alavanja MC (2017) Occupational exposure to pesticides and the incidence of lung cancer in the agricultural health study. Environ Health Perspect 125:544–551CrossRefGoogle Scholar
  12. Bucchi L, Nanni O, Ravaioli A, Falcini F, Ricci R, Buiatti E, Amadori D (2004) Cancer mortality in a cohort of male agricultural workers from northern Italy. J Occup Environ Med 46:249–256CrossRefGoogle Scholar
  13. Cabidoche Y-M, Achard R, Cattan P, Clermont-Dauphin C, Massat F, Sansoulet J (2009) Long-term pollution by chlordecone of tropical volcanic soils in the French West Indies: a simple leaching model accounts for current residue. Environ Pollut 157:1697–1705CrossRefGoogle Scholar
  14. Checkoway H, Pearce N, Kriebel D (2004) Research methods in occupational epidemiology (monographs in epidemiology and biostatistics), 2nd edn. Oxford University Press, New YorkCrossRefGoogle Scholar
  15. Coat S, Monti D, Legendre P, Bouchon C, Massat F, Lepoint G (2011) Organochlorine pollution in tropical rivers (Guadeloupe): role of ecological factors in food web bioaccumulation. Environ Pollut 159:1692–1701CrossRefGoogle Scholar
  16. Dubuisson C, Héraud F, Leblanc J-C, Gallotti S, Flamand C, Blateau A, Quenel P, Volatier J-L (2007) Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to Chlordecone. Regul Toxicol Pharmacol 49:5–16CrossRefGoogle Scholar
  17. Eurostat, Statistical Office of the European Communities (2012) European shortlist for causes of death. Available at: http://ec.europa.eu/eurostat/ramon/nomenclatures/index.cfm. Accessed 9 Jul 2019
  18. Gentil C, Spinosi J, Cahour L, Chaperon L, El Yamani M (2018) Document technique pour la construction de la matrice culture exposition de la Banane dessert aux Antilles. Projet Matphyto DOM. Saint-Maurice : Santé Publique France, 44 p. Available at: http://invs.santepubliquefrance.fr/content/download/150514/547924/version/11/file/guide-construction-matrice-culture-exposition-banane-dessert-antilles.pdf. Accessed 9 Jul 2019
  19. Guillien A, Soumagne T, Dalphin J-C, Degano B (2019) COPD, airflow limitation and chronic bronchitis in farmers: a systematic review and meta-analysis. Occup Environ Med 76:58–68CrossRefGoogle Scholar
  20. Guldner L, Multigner L, Héraud F, Monfort C, Thomé JP, Giusti A, Kadhel P, Cordier S (2010) Pesticide exposure of pregnant women in Guadeloupe: ability of a food frequency questionnaire to estimate blood concentration of chlordecone. Environ Res 110:146–151CrossRefGoogle Scholar
  21. Hofmann J, Guardado J, Keifer M, Wesseling C (2006) Mortality among a cohort of banana plantation workers in Costa Rica. Int J Occup Environ Health 12:321–328CrossRefGoogle Scholar
  22. Kachuri L, Harris MA, MacLeod JS, Tjepkema M, Peters PA, Demers PA (2017) Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and environment cohort (CanCHEC). BMC Cancer 17:1–15CrossRefGoogle Scholar
  23. Keller-Byrne JE, Khuder SA, Schaub EA (1997) Meta-analyses of prostate cancer and farming. Am J Ind Med 31:580–586CrossRefGoogle Scholar
  24. Khuder SA, Mutgi AB (1997) Meta-analyses of multiple myeloma and farming. Am J Ind Med 32:510–516CrossRefGoogle Scholar
  25. Khuder SA, Schaub EA, Keller-Byrne JE (1998) Meta-analyses of non-Hodgkin’s lymphoma and farming. Scand J Work Environ Health 24:255–261CrossRefGoogle Scholar
  26. Klingelschmidt J, Milner A, Khireddine-Medouni I, Witt K, Alexopoulos EC, Toivanen S, LaMontagne AD, Chastang J-F, Niedhammer I (2018) Suicide among agricultural, forestry, and fishery workers: a systematic literature review and meta-analysis. Scand J Work Environ Health 44:3–15CrossRefGoogle Scholar
  27. Krawczyk N, de Souza Espíndola Santos A, Lima J, Meyer A (2017) Revisiting cancer 15 years later: exploring mortality among agricultural and non-agricultural workers in the Serrana Region of Rio de Janeiro. Am J Ind Med 60:77–86CrossRefGoogle Scholar
  28. Le Déault JY, Procaccia C (2009) Impacts de l'utilisation de la chlordécone et des pesticides aux Antilles : bilan et perspectives d'évolution. Rapport de l'Office parlementaire d'évaluation des choix scientifiques et technologiques, n°487. Available at: https://www.senat.fr/rap/r08-487/r08-487.html. Accessed 9 Jul 2019
  29. Levêque-Morlais N, Tual S, Clin B, Adjemian A, Baldi I, Lebailly P (2015) The AGRIculture and CANcer (AGRICAN) cohort study: enrollment and causes of death for the 2005-2009 period. Int Arch Occup Environ Health 88:61–73CrossRefGoogle Scholar
  30. Milner A, Spittal MJ, Pirkis J, LaMontagne AD (2013) Suicide by occupation: systematic review and meta-analysis. Br J Psychiatry 203:409–416CrossRefGoogle Scholar
  31. Multigner L, Ndong JR, Giusti A, Romana M, Delacroix-Maillard H, Cordier S, Jégou B, Thome JP, Blanchet P (2010) Chlordecone exposure and risk of prostate cancer. J Clin Oncol 28:3457–3462CrossRefGoogle Scholar
  32. Multigner L, Kadhel P, Rouget F, Blanchet P, Cordier S (2016) Chlordecone exposure and adverse effects in French West Indies populations. Environ Sci Pollut Res Int 23:3–8CrossRefGoogle Scholar
  33. Richard JB (2015) Premiers résultats du Baromètre santé DOM 2014 - Résultats détaillés selon le DOM, l'âge et le sexe. Saint-Maurice: Santé publique France. Available at: http://inpes.santepubliquefrance.fr/CFESBases/catalogue/pdf/1662.pdf. Accessed 9 Jul 2019
  34. Van Maele-Fabry G, Willems JL (2003) Occupation related pesticide exposure and cancer of the prostate; a meta-analysis. Occup Environ Med 9:634–642CrossRefGoogle Scholar
  35. Van Maele-Fabry G, Duhayon S, Lison LD (2007) A systematic review of myeloid leukemias and occupational pesticide exposure. Cancer Causes Control 18:457–478CrossRefGoogle Scholar
  36. Van Maele-Fabry G, Hoet P, Vilain F, Lison D (2012) Occupational exposure to pesticides and Parkinson’s disease: a systematic review and meta-analysis of cohort studies. Environment International 46:30–43CrossRefGoogle Scholar
  37. Waggoner JK, Kullman GJ, Henneberger PK, Umbach DM, Blair A, Alavanja MC et al (2011) Mortality in the agricultural health study, 1993–2007. Am J Epidemiol 173:71–83CrossRefGoogle Scholar
  38. Wesseling C, Ahlbom A, Antich D, Rodriguez AC, Castro R (1996) Cancer in banana plantation workers in Costa Rica. Int J Epidemiol 25:1125–1131CrossRefGoogle Scholar
  39. Yan D, Zhang Y, Liu L, Yan H (2016) Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis. Sci Rep 6:32222CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085Pointe-à-PitreFrance
  2. 2.Santé Publique FranceSaint-MauriceFrance
  3. 3.Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085RennesFrance

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