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The lag effect of water pollution on the mortality rate for esophageal cancer in a rapidly industrialized region in China

  • Chengdong Xu
  • Dingfan Xing
  • Jinfeng WangEmail author
  • Gexin XiaoEmail author
Research Article
  • 32 Downloads

Abstract

The Huai River basin (located in eastern China) has a population of 180 million and has the highest risk of esophageal cancer (EC) mortality in China. Some studies found that contaminants in drinking water are a major risk factor for cancers of the digestive system. However, the effect of water pollution in the historical period on the current EC mortality remains unclear. Data were collected on the EC mortality rate in 2004 in the Huai River basin in 11 counties, and data on the surface water quality in the region from 1987 to 2004 were used. The Pearson correlation and the GeoDetector q-statistic were employed to explore the association between water pollution and the EC mortality rate in different lag periods, from linear and nonlinear perspectives, respectively. The study showed apparently spatial heterogeneity of the EC mortality rate in the region. The EC mortality rate downstream is significantly higher than that in other regions; in the midstream, the region north of the mainstream has a lower average mortality rate than that south of the area. Upstream, the region north of the mainstream has a higher mortality rate than that in the southern area. The spatial pattern was formed under the influence of water pollution in the historical period. 1996, 1997, and 1998 have the strongest linear or nonlinear effect on the EC mortality rate in 2004, in which the Pearson correlation coefficient and the q-statistic were the highest, 0.79 and 0.89, respectively. Rapid industrialization in the past 20 years has caused environmental problems and poses related health risks. The study indicated that the current EC mortality rate was mainly caused by water pollution from the previous 8 years. The findings provide knowledge about the lag time for pollution effects on the EC mortality rate, and can contribute to the controlling and preventing esophageal cancer.

Keywords

Esophageal cancer Lag effect Water pollution Spatial analysis Rapid industrialization 

Abbreviations

EC

esophageal cancer

Notes

Authors’ contribution

CDX and DFX conceived and designed the study. DFX and CDX conducted the main analyses. JFW and GXX contributed to refining the ideas and carrying out additional analyses. All authors discussed the results and revised the manuscript.

Funding information

This study was financially supported by the following grants: National Natural Science Foundation of China (41531179, 41601419) and the LREIS Innovation Project (O88RA205YA, O88RA200YA).

Compliance with ethical standards

Competing interests

The authors declare that they have no competing interests.

References

  1. Beaumont JJ, Sedman RM, Reynolds SD, Sherman CD, Li LH, Howd RA, Sandy MS, Zeise L, Alexeeff GV (2008) Cancer mortality in a Chinese population exposed to hexavalent chromium in drinking water. Epidemiology 19(1):12–23.  https://doi.org/10.1097/EDE.0b013e31815cea4c CrossRefGoogle Scholar
  2. Bruningfann CS, Kaneene JB (1993) The effects of nitrate, nitrite and N-nitroso compounds on human health: a review. Vet Hum Toxicol 35(6):521–538Google Scholar
  3. Cai HS, Liu CF, Zhou AG, Yang Y (2002) Study of correlation for the no_3~-contamination of drinking water and for the rate of disease and death of esophagus cancer of Linzhou and Anyang in Henan Province. Geol Sci & Tech Inf 21(1):91–94Google Scholar
  4. Di PB, Bronson NW, Diggs BS, Jr TC, Hunter JG, Dolan JP (2016) The global burden of esophageal cancer: a disability-adjusted life-year approach. World J Surg 40(2):395–401.  https://doi.org/10.1007/s00268-015-3356-2 CrossRefGoogle Scholar
  5. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893–2917CrossRefGoogle Scholar
  6. Fu BJ, Zhuang XL, Jiang GB, Shi JB, Lu YH (2007) Environmental problems and challenge in China. Environ Sci Technol 41(22):7597–7602.  https://doi.org/10.1002/ijc.25516 CrossRefGoogle Scholar
  7. Gao X, Wang Z, Kong C, Yang F, Wang Y, Tan X (2017) Trends of esophageal cancer mortality in rural China from 1989 to 2013: an age-period-cohort analysis. Int J Environ Res Public Health 14(3).  https://doi.org/10.3390/ijerph14030218
  8. Huang X, Guan S, Wang J, Zhao L, Jia Y, Lu Z, Yin C, Yang S, Song Q, Han L, Wang C, Li J, Zhou W, Guo X, Cheng Y (2017) The effects of air pollution on mortality and clinicopathological features of esophageal cancer. Malawi Med J 29(2):212–217.  https://doi.org/10.18632/oncotarget.17266 CrossRefGoogle Scholar
  9. Keshavarzi B, Moore F, Najmeddin A, Rahmani F (2012) The role of selenium and selected trace elements in the etiology of esophageal cancer in high risk Golestan province of Iran. Sci Total Environ 433:89–97CrossRefGoogle Scholar
  10. Lu SH, Ohshima H, Fu HM, Tian Y, Li FM, Blettner M, Wahrendorf J, Bartsch H (1986) Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for esophageal cancer in Northern China: endogenous formation of nitrosoproline and its inhibition by vitamin C. Cancer Res 46(3):1485Google Scholar
  11. Murphy AP (1991) Chemical removal of nitrate from water. Nature 350(6315):223–225.  https://doi.org/10.1038/350223a0 CrossRefGoogle Scholar
  12. Pan G, Takahashi K, Feng Y, Liu L, Liu T, Zhang S, Liu N, Okubo T, Goldsmith DF (1999) Nested case-control study of esophageal cancer in relation to occupational exposure to silica and other dusts. Am J Epidemiol 150(5):443–452CrossRefGoogle Scholar
  13. Pennathur A, Gibson MK, Jobe BA, Luketich JD (2013) Oesophageal carcinoma. Lancet 381(9864):400–412.  https://doi.org/10.1016/S0140-6736(12)60643-6 CrossRefGoogle Scholar
  14. Ping zJ (2004) China regional economic statistics yearbook. Ocean PressGoogle Scholar
  15. Reid BJ, Li XH, Galipeau PC, Vaughan TL (2010) Barrett’s oesophagus and oesophageal adenocarcinoma: time for a new synthesis. Nat Rev Cancer 10(2):87–101.  https://doi.org/10.1038/nrc2773 CrossRefGoogle Scholar
  16. Ribeiro U, Posner MC, SafatleRibeiro AV, Reynolds JC (1996) Risk factors for squamous cell carcinoma of the oesophagus. Br J Surg 83(9):1174–1185CrossRefGoogle Scholar
  17. Semnani S, Roshandel G, Zendehbad A, Keshtkar A, Rahimzadeh H, Abdolahi N, Besharat S, Moradi A, Mirkarimi H, Hasheminasab S (2010) Soils selenium level and esophageal cancer: an ecological study in a high risk area for esophageal cancer. J Trace Elem Med Biol 24(3):174–177.  https://doi.org/10.1016/j.jtemb.2010.03.002 CrossRefGoogle Scholar
  18. Shao M, Tang XY, Zhang YH, Li WJ (2006) City clusters in China: air and surface water pollution. Front Ecol Environ 4(7):353–361CrossRefGoogle Scholar
  19. Simeonov V, Stratis JA, Samara C, Zachariadis G, Voutsa D, Anthemidis A, Sofoniou M, Kouimtzis T (2003) Assessment of the surface water quality in Northern Greece. Water Res 37(17):4119–4124.  https://doi.org/10.1016/S0043-1354(01)00062-8 CrossRefGoogle Scholar
  20. Sliva L, Williams DD (2001) Buffer zone versus whole catchment approaches to studying land use impact on river water quality. Water Res 35(14):3462–3472CrossRefGoogle Scholar
  21. Tan B, Wu P, Song G (2005) Water pollution in Huaihe basin and its prevention and control. Water resources protection 21(6):4–10Google Scholar
  22. Tao X, Zhu H, Matanoski GM (2000) Mutagenic drinking water and risk of male esophageal cancer: a population-based case-control study. Chin J Epidemiol 21(6):434–436Google Scholar
  23. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65(2):87–108.  https://doi.org/10.3322/caac.21262 CrossRefGoogle Scholar
  24. van Maanen JMS, Welle IJ, Hageman G, Dallinga JW, Mertens P, Kleinjans JCS (1996) Nitrate contamination of drinking water: relationship with HPRT variant frequency in lymphocyte DNA and urinary excretion of N-nitrosamines. Environ Health Perspect 104(5):522–528.  https://doi.org/10.2307/3432993 CrossRefGoogle Scholar
  25. Wang JF, Li XH, Christakos G, Liao YL, Zhang T, Gu X, Zheng XY (2010) Geographical detectors-based health risk assessment and its application in the neural tube defects study of the Heshun Region, China. Int J Geogr Inf Sci 24(1):107–127.  https://doi.org/10.1080/13658810802443457 CrossRefGoogle Scholar
  26. Wang JF, Zhang TL, Fu BJ (2016) A measure of spatial stratified heterogeneity. Ecol Indic 67:250–256.  https://doi.org/10.1016/j.ecolind.2016.02.052 CrossRefGoogle Scholar
  27. Wang Q, Wang J, Zhou J, Ban J, Li T (2019) Estimation of PM2·5-associated disease burden in China in 2020 and 2030 using population and air quality scenarios: a modelling study. The Lancet Planetary health 3(2):e71–e80Google Scholar
  28. Wei W-q, Yang J, Zhang S-w, Chen W-q, Qiao Y-l (2010) Analysis of the esophageal cancer mortality in 2004–2005 and its trends during last 30 years in China. Chin J of Prevent Med 44(5):398–402Google Scholar
  29. Weinmayr G, Pedersen M, Stafoggia M, Andersen ZJ, Galassi C, Munkenast J, Jaensch A, Oftedal B, Krog NH, Aamodt G, Pyko A, Pershagen G, Korek M, De Faire U, Pedersen NL, Ostenson C-G, Rizzuto D, Sorensen M, Tjonnel A, Bueno-de-Mesquita B, Vermeulen R, Eeftens M, Concin H, Lang A, Wang M, Tsai M-Y, Ricceri F, Sacerdote C, Ranzi A, Cesaroni G, Forastiere F, de Hoogh K, Beelen R, Vineis P, Kooter I, Sokhi R, Brunekreef B, Hoek G, Raaschou-Nielsen O, Nagel G (2018) Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution Effects (ESCAPE). Environ Int 120:163–171.  https://doi.org/10.1016/j.envint.2018.07.030 CrossRefGoogle Scholar
  30. Yang CY, Wu DC, Chang CC (2007) Nitrate in drinking water and risk of death from colon cancer in Taiwan. Environ Int 33(5):649–653.  https://doi.org/10.1016/j.envint.2007.01.009 CrossRefGoogle Scholar
  31. Yang G, Zhuang D (2014) Research on the Correlation between Cancer and the Huai River Water Environment. In: Yang G, Zhuang D, eds. Atlas of the Huai River Basin Water Environment: Digestive Cancer Mortality. Dordrecht: Springer Netherlands : 1–26 Google Scholar
  32. Zatonski W, Ohshima H, Przewozniak K, Drosik K, Mierzwinska J, Krygier M, Chmielarczyk W, Bartsch H (1989) Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for stomach cancer in Poland. Int J Cancer 44(5):823–827Google Scholar
  33. Zhang XL, Bing Z, Xing Z, Chen ZF, Zhang JZ, Liang SY, Men FS, Zheng SL, Li XP, Bai XL (2003) Research and control of well water pollution in high esophageal cancer areas. MedGenMed 5(1):20.  https://doi.org/10.3748/wjg.v9.i6.1187 Google Scholar
  34. Zhang JF, Mauzerall DL, Zhu T, Liang S, Ezzati M, Remais JV (2010) Environmental health in China: progress towards clean air and safe water. Lancet 375(9720):1110–1119.  https://doi.org/10.1016/S0140-6736(10)60062-1 CrossRefGoogle Scholar
  35. Zhang XY, Zhuang DF, Ma X, Jiang D (2014) Esophageal cancer spatial and correlation analyses: water pollution, mortality rates, and safe buffer distances in China. J Geogr Sci 24(1):46–58.  https://doi.org/10.1007/s11442-014-1072-8 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingChina
  2. 2.School of Information EngineeringChina University of GeosciencesBeijingChina
  3. 3.China National Center For Food Safety Risk AssessmentBeijingChina

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