Advertisement

The influence of selected pharmaceuticals on biogas production from laboratory and real anaerobic sludge

  • Milota Fáberová
  • Lucia Ivanová
  • Petra Szabová
  • Magdalena Štolcová
  • Igor BodíkEmail author
Research Article
  • 28 Downloads

Abstract

The presented study summarizes laboratory tests results to define the inhibition effect of selected pharmaceuticals on biogas production under anaerobic digestion conditions. Two sets of inhibition tests were realized: (i) with real anaerobic sludge (from municipal wastewater treatment plant (WWTP) where sludge is present and includes a wide spectrum of pharmaceuticals over a long period) and (ii) with laboratory sludge (sludge without pharmaceuticals). Methanogenic tests lasting 20 days were performed with three analgesics (diclofenac, ibuprofen, and tramadol), two antibiotics (amoxicillin and ciprofloxacin), β-blocker (atenolol), three psychoactive compounds (carbamazepine, caffeine, and cotinine), and a mixture of these compounds. All tests were performed with two concentrations of pharmaceuticals (10 μg/L and 500 μg/L). Results of the methanogenic tests showed the different behaviors of the investigated sludges in the presence of individual pharmaceuticals. Stimulation of anaerobic digestion was mostly detected for laboratory (unadapted) sludge (e.g., the addition of ibuprofen at a concentration of 500 μg/L increased biogas production by 61%). On the other hand, pharmaceuticals inhibited biogas production for real sludge (e.g., the addition of ciprofloxacin 500 μg/L decreased biogas production by 52%).

Keywords

Sewage sludge Anaerobic fermentation Micropollutants Inhibition Stimulation Wastewater 

Notes

Funding information

This work was supported by the Slovak Research and Development Agency under the contract no. APVV 0122-12 and APVV 17-119.

References

  1. Appels L, Baeyens J, Degrève J, Dewil R (2008) Principles and potential of the anaerobic digestion of waste-activated sludge. Prog Energy Combust Sci 34:755–781.  https://doi.org/10.1016/j.pecs.2008.06.002 CrossRefGoogle Scholar
  2. Baker DR, Barron L, Kasprzyk-Hordern B (2014) Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part A: chemical analysis and drug use estimates. Sci Total Environ 487:629–641.  https://doi.org/10.1016/j.scitotenv.2013.11.107 CrossRefGoogle Scholar
  3. Chen Y, Cheng JJ, Creamer KS (2008) Inhibition of anaerobic digestion process: a review. Bioresour Technol 99:4044–4064.  https://doi.org/10.1016/j.biortech.2007.01.057 CrossRefGoogle Scholar
  4. Chen JL, Ortiz R, Steele TWJ, Stuckey DC (2014) Toxicants inhibiting anaerobic digestion: a review. Biotechnol Adv 32:1523–1534.  https://doi.org/10.1016/j.biotechadv.2014.10.005 CrossRefGoogle Scholar
  5. Fedorova G, Randak T, Lindberg RH, Grabic R (2013) Comparison of the quantitative performance of a Q-Exactive high-resolution mass spectrometer with that of a triple quadrupole tandem mass spectrometer for the analysis of illicit drugs in wastewater. Rapid Commun Mass Spectrom 27:1751–1762.  https://doi.org/10.1002/rcm.6628 CrossRefGoogle Scholar
  6. Fountoulakis M, Drilla P, Stamatelatou K, Lyberatos G (2004) Toxic effect of pharmaceuticals on methanogenesis. Water Sci Technol 50:335–340CrossRefGoogle Scholar
  7. Gartiser S, Urich E, Alexy R, Kümmerer K (2007) Anaerobic inhibition and biodegradation of antibiotics in ISO test schemes. Chemosphere 66:1839–1848.  https://doi.org/10.1016/j.chemosphere.2006.08.040 CrossRefGoogle Scholar
  8. Golovko O, Koba O, Kodesova R, Fedorova G, Kumar V, Grabic R (2016) Development of fast and robust multiresidual LC-MS/MS method for determination of pharmaceuticals in soils. Environ Sci Pollut Res 23:14068–14077.  https://doi.org/10.1007/s11356-016-6487-6 CrossRefGoogle Scholar
  9. ISO 13641-1 (2003) Water quality – determination of inhibition of gas production of anaerobic bacteria – part 1Google Scholar
  10. Ivanová L, Fáberová M, Mackuľak T, Grabic R, Bodík I (2017) Estimation of amount of selected pharmaceuticals sorbed onto digested sludge from wastewater treatment plant Bratislava-Petržalka. Environ Res 155:31–35.  https://doi.org/10.1016/j.envres.2017.02.001 CrossRefGoogle Scholar
  11. Ivanová L, Mackuľak T, Grabic R, Golovko O, Koba O, Staňová AV, Szabová P, Grenčíková A, Bodík I (2018) Pharmaceuticals and illicit drugs – a new threat to the application of sewage sludge in agriculture. Sci Total Environ 634:606–615.  https://doi.org/10.1016/j.scitotenv.2018.04.001 CrossRefGoogle Scholar
  12. Khan SJ, Ongerth JE (2002) Estimation of pharmaceutical residues in primary and secondary sewage sludge based on quantities of use and fugacity modelling. Water Sci Technol 46:105–113.  https://doi.org/10.2166/wst.2002.0065 CrossRefGoogle Scholar
  13. Kim J, Kim H, Baek G, Lee C (2017) Anaerobic co-digestion of spent coffee grounds with different waste feedstocks for biogas production. Waste Management 60:322–328.  https://doi.org/10.1016/j.wasman.2016.10.015 CrossRefGoogle Scholar
  14. Kwietniewska E, Tys J (2014) Process characteristics, inhibition factors and methane yields of anaerobic digestion process, with particular focus on microalgal biomass fermentation. Renew Sustain Energy Rev 34:491–500.  https://doi.org/10.1016/j.rser.2014.03.041 CrossRefGoogle Scholar
  15. Lallai A, Mura G, Onnis N (2002) The effects of certain antibiotics on biogas production in the anaerobic digestion of pig waste slurry. Bioresour Technol 82:205–208.  https://doi.org/10.1016/S0960-8524(01)00162-6 CrossRefGoogle Scholar
  16. Liu J-L, Wong M-H (2013) Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China. Environ Int 59:208–224.  https://doi.org/10.1016/j.envint.2013.06.012 CrossRefGoogle Scholar
  17. Martín J, Santos JL, Aparicio I, Alonso E (2015) Pharmaceutically active compounds in sludge stabilization treatments: anaerobic and aerobic digestion, wastewater stabilization ponds and composting. Sci Total Environ 503–504:97–104.  https://doi.org/10.1016/j.scitotenv.2014.05.089 CrossRefGoogle Scholar
  18. Paíga P, Correia M, Fernandes MJ, Silva A, Carvalho M, Vieira J, Jorge S, Silva JG, Freire C, Delerue-Matos C (2019) Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: hourly variation. Sci Total Environ 648:582–600.  https://doi.org/10.1016/j.scitotenv.2018.08.129 CrossRefGoogle Scholar
  19. Park J, Yamashita N, Park C, Shimono T, Takeuchi DM, Tanaka H (2017) Removal characteristics of pharmaceuticals and personal care products: comparison between membrane bioreactor and various biological treatment processes. Chemosphere 179:347–358.  https://doi.org/10.1016/j.chemosphere.2017.03.135 CrossRefGoogle Scholar
  20. Raposo F, De la Rubia MA, Fernández-Cegrí V, Borja R (2012) Anaerobic digestion of solid organic substrates in batch mode: an overview relating to methane yields and experimental procedures. Renew Sustain Energy Rev 16:861–877.  https://doi.org/10.1016/j.rser.2011.09.008 CrossRefGoogle Scholar
  21. Sanz JL, Rodriguez N, Amils R (1996) The action of antibiotics on the anaerobic digestion process. Appl Microbiol Biotechnol 46:587–592.  https://doi.org/10.1007/s002530050865 CrossRefGoogle Scholar
  22. Stamatelatou K, Frouda C, Fountoulakis M et al (2003) Pharmaceuticals and health care products in wastewater effluents: the example of carbamazepine. Water Sci Technol Water Supply 3:131–137.  https://doi.org/10.2166/ws.2003.0054 CrossRefGoogle Scholar
  23. Stasinakis AS (2012) Review on the fate of emerging contaminants during sludge anaerobic digestion. Bioresour Technol 121:432–440.  https://doi.org/10.1016/j.biortech.2012.06.074 CrossRefGoogle Scholar
  24. Stuckey DC, Owen WF, McCarty PL (1980) Anaerobic toxicity evaluation by batch and semi-continuous assays. J Water Pollut Control Fed 52:720–729Google Scholar
  25. Tran NH, Gin KY-H (2017) Occurrence and removal of pharmaceuticals, hormones, personal care products, and endocrine disrupters in a full-scale water reclamation plant. Sci Total Environ 599–600:1503–1516.  https://doi.org/10.1016/j.scitotenv.2017.05.097 CrossRefGoogle Scholar
  26. van Lier JB, Tilche A, Ahring BK, Macarie H, Moletta R, Dohanyos M, Hulshoff Pol LW, Lens P, Verstraete W (2001) New perspectives in anaerobic digestion. Water Sci Technol 43:1–18CrossRefGoogle Scholar
  27. Verlicchi P, Zambello E (2015) Pharmaceuticals and personal care products in untreated and treated sewage sludge: occurrence and environmental risk in the case of application on soil - a critical review. Sci Total Environ 538:750–767.  https://doi.org/10.1016/j.scitotenv.2015.08.108 CrossRefGoogle Scholar
  28. Verlicchi P, Al Aukidy M, Zambello E (2012) Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment-a review. Sci Total Environ 429:123–155.  https://doi.org/10.1016/j.scitotenv.2012.04.028 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Environmental Engineering, Faculty of Chemical and Food TechnologySlovak University of Technology in BratislavaBratislavaSlovak Republic
  2. 2.Department of Organic Technology, Faculty of Chemical and Food TechnologySlovak University of Technology in BratislavaBratislavaSlovak Republic

Personalised recommendations