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Environmental Science and Pollution Research

, Volume 26, Issue 18, pp 18200–18207 | Cite as

Gallic acid protects particulate matter (PM10) triggers cardiac oxidative stress and inflammation causing heart adverse events in rats

  • Maryam Radan
  • Mahin DianatEmail author
  • Mohammad Badavi
  • Seyyed Ali Mard
  • Vahid Bayati
  • Gholamreza Goudarzi
Research Article
  • 68 Downloads

Abstract

Previous studies have shown that exposure to particulate matter (PM) increased variety of health problems, particularly cardiovascular diseases leading to premature mortality. The cardiac effects of particulate matter containing PM10 include increased infarct size, decreased heart function, and increased arrhythmias in experimental ischemia-reperfusion models in rats. The aim of this study was to evaluate the effects of particles with an aerodynamic diameter smaller than 10 μm (PM10) on isolated-rat heart and also to determine the efficacy of gallic acid (GA) as a preventive agent in oxidative damage. The healthy rats were divided into 8 equal groups which served as, control, GA, PM10 (0.5, 2.5, and 5 mg/kg), and PM10+GA groups. PM10 administered into the lungs via the trachea in two stages with 48-h interval. After all experiments, the electrocardiogram was recorded. Then, the hemodynamic parameters and ventricular arrhythmias in rat isolated-hearts were assessed using Langendorff apparatus and according to the Lambeth conventions. In addition, the inflammation and oxidative stress factors in cardiac tissues were evaluated in all groups. The obtained results showed that the exposure to PM caused to decrease in cardiac hemodynamic and electrocardiogram parameters. Also, in PM10 rat groups, the IL-6, TNF-α, and oxidative stress parameters were increased. Gallic acid preserved the value of cardiac parameters and inflammation in rat hearts. In summary, we added a novel therapeutic effect of gallic acid for cardiac dysfunction induced by particulate matter. These findings could be related to antioxidant and antiinflammation properties and the obtained results suggest that natural antioxidant like gallic acid could be a therapeutic agent in prevention and management of health issues in the polluted areas of the world.

Keywords

Gallic acid Particulate matter Inflammation Oxidative stress Rat 

Notes

Acknowledgments

This study was done in the Persian Gulf Physiology Research Center at Ahvaz Jundishapur University of Medical Sciences in Ahvaz, Iran.

Funding information

Authors received help and financial support from Ministry of Health and Medical Education and Persian Gulf Physiology Research Center of Ahvaz Jundishapur University of Medical Sciences (Grant No. APRC-9515).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Maryam Radan
    • 1
  • Mahin Dianat
    • 1
    Email author
  • Mohammad Badavi
    • 1
  • Seyyed Ali Mard
    • 1
  • Vahid Bayati
    • 2
  • Gholamreza Goudarzi
    • 3
  1. 1.Department of Physiology, Physiology Research Center, Faculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran
  2. 2.Cellular and Molecular Research Center, Faculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran
  3. 3.Department of Environmental Health Engineering, Health FacultyAhvaz Jundishapur University of Medical SciencesAhvazIran

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