Advertisement

Environmental Science and Pollution Research

, Volume 26, Issue 19, pp 19697–19704 | Cite as

Effects of short- and long-term exposures to particulate matter on inflammatory marker levels in the general population

  • Dai-Hua Tsai
  • Michael Riediker
  • Antoine Berchet
  • Fred Paccaud
  • Gerard Waeber
  • Peter Vollenweider
  • Murielle BochudEmail author
Research Article

Abstract

The effect of particulate matter (PM) on health increases with exposure duration but the change from short to longer term is not well studied. We examined the exposure to PM smaller 10 μm (PM10) from short to longer duration and their associations with levels of inflammatory markers in the population-based CoLaus cohort in Lausanne, Switzerland. Baseline and follow-up CoLaus data were used to study the associations between PM10 exposure and inflammatory markers, including the high-sensitivity C-reactive protein (CRP), as well as interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) using mixed models. Exposure was determined for each participant’s home address from hourly air quality simulations at a 5-m resolution. Short-term exposure intervals were 1 day, 1 week, and 1 month prior to the hospital visit (blood withdrawal); long-term exposure intervals were 3 and 6 months prior to the visit. In most time windows, IL-6, IL-1β, and TNF-α were positively associated with PM10. No significant associations were identified for CRP. Adjusted associations with long-term exposures were stronger and more significant than those for short-term exposures. In stratified models, gender, age, smoking status, and hypertension only led to small modifications in effect estimates, though a few of the estimates for IL-6 and TNF-α became non-significant. In this general adult cohort exposed to relatively low average PM10 levels, clear associations with markers of systemic inflammation were observed. Longer duration of elevated exposure was associated with an exacerbated inflammatory response. This may partially explain the elevated disease risk observed with chronic PM10 exposure. It also suggests that reducing prolonged episodes of high PM exposure may be a strategy to reduce inflammatory risk.

Keywords

Particulate matter Inflammation Short-term Long-term Modeling Air pollution 

Notes

Acknowledgments

We express our gratitude to participants in the CoLaus studies and to the healthcare professionals and collaborators who have contributed to the data collection. We thank MeteoSwiss for providing the meteorological data and the National Air Pollution Monitoring Network (NABEL) for providing air pollution data in Lausanne. We thank the Direction Générale du Canton de Vaud for providing in situ data and a pollution inventory for the city of Lausanne.

Funding information

The CoLaus study was and is supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and the Swiss National Science Foundation (grants 33CSCO-122661, 33CS30-139468, and 33CS30-148401). We also thank the funding from Nano-Tera.ch to support Dai-Hua Tsai for doing this work (grant RTD2013: 20NA20_150956).

Supplementary material

11356_2019_5194_MOESM1_ESM.docx (302 kb)
ESM 1 (DOCX 302 kb)

References

  1. Becker S, Mundandhara S, Devlin R, Madden M (2005) Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies. Toxicol Appl Pharmacol 207:269–275CrossRefGoogle Scholar
  2. Berchet A, Zink K, Muller C, Oettl D, Brunner J, Emmenegger L et al (2017) A cost-effective method for simulating city-wide air flow and pollutant dispersion at building resolving scale. Atmos Environ 158:181–196CrossRefGoogle Scholar
  3. Bermudez EA, Rifai N, Buring J, Manson JE, Ridker PM (2002) Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women. Arterioscler Thromb Vasc Biol 22:1668–1673CrossRefGoogle Scholar
  4. Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV et al (2010) Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the american heart association. Circulation 121:2331–2378CrossRefGoogle Scholar
  5. Chen JC, Schwartz J (2008) Metabolic syndrome and inflammatory responses to long-term particulate air pollutants. Environ Health Perspect 116:612–617CrossRefGoogle Scholar
  6. Chuang KJ, Yan YH, Chiu SY, Cheng TJ (2011) Long-term air pollution exposure and risk factors for cardiovascular diseases among the elderly in Taiwan. Occup Environ Med 68:64–68CrossRefGoogle Scholar
  7. Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB et al (2004) Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc 52:1098–1104CrossRefGoogle Scholar
  8. Culyba AJ, Guo W, Branas CC, Miller E, Wiebe DJ (2018) Comparing residence-based to actual path-based methods for defining adolescents’ environmental exposures using granular spatial data. Health Place 49:39–49CrossRefGoogle Scholar
  9. Diez-Roux A, Auchincloss A, Astor B, Barr R, Cushman M, Dvonch T et al (2006) Recent exposure to particulate matter and C-reactive protein concentration in the multi-ethnic study of atherosclerosis. Am J Epidemiol 164:437–448CrossRefGoogle Scholar
  10. Firmann M, Mayor V, Vidal PM, Bochud M, Pecoud A, Hayoz D et al (2008) The Colaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord 8:6CrossRefGoogle Scholar
  11. Forbes LJL, Patel MD, Rudnicka AR, Cook DG, Bush T, Stedman JR et al (2009) Chronic exposure to outdoor air pollution and markers of systemic inflammation. Epidemiology 20:245–253CrossRefGoogle Scholar
  12. Grabiec AM, Hussell T (2016) The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation. Semin Immunopathol 38(4):409–423CrossRefGoogle Scholar
  13. Green R, Broadwin R, Malig B, Basu R, Gold EB, Qi L et al (2016) Long- and short-term exposure to air pollution and inflammatory/hemostatic markers in midlife women. Epidemiology 27:211–220Google Scholar
  14. Hajat A, Allison M, Diez-Roux AV, Jenny NS, Jorgensen NW, Szpiro AA et al (2015) Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the multi-ethnic study of atherosclerosis (MESA). Epidemiology 26:310–320CrossRefGoogle Scholar
  15. Hassanvand MS, Naddafi K, Kashani H, Faridi S, Kunzli N, Nabizadeh R et al (2017) Short-term effects of particle size fractions on circulating biomarkers of inflammation in a panel of elderly subjects and healthy young adults. Environ Pollut 223:695–704CrossRefGoogle Scholar
  16. Hennig F, Fuks K, Moebus S, Weinmayr G, Memmesheimer M, Jakobs H et al (2014) Association between source-specific particulate matter air pollution and hs-crp: local traffic and industrial emissions. Environ Health Perspect 122:703–710CrossRefGoogle Scholar
  17. Hertel S, Viehmann A, Moebus S, Mann K, Brocker-Preuss M, Mohlenkamp S et al (2010) Influence of short-term exposure to ultrafine and fine particles on systemic inflammation. Eur J Epidemiol 25:581–592CrossRefGoogle Scholar
  18. Hoffmann B, Moebus S, Dragano N, Stang A, Mohlenkamp S, Schmermund A et al (2009) Chronic residential exposure to particulate matter air pollution and systemic inflammatory markers. Environ Health Perspect 117:1302–1308CrossRefGoogle Scholar
  19. Imrich A, Ning Y, Lawrence J, Coull B, Gitin E, Knutson M et al (2007) Alveolar macrophage cytokine response to air pollution particles: oxidant mechanisms. Toxicol Appl Pharmacol 218:256–264CrossRefGoogle Scholar
  20. Kaptoge S, Seshasai SR, Gao P, Freitag DF, Butterworth AS, Borglykke A et al (2014) Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. Eur Heart J 35(9):578–589CrossRefGoogle Scholar
  21. Kofler S, Nickel T, Weis M (2005) Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation. Clin Sci 108:205–213CrossRefGoogle Scholar
  22. Lanki T, Hampel R, Tiittanen P, Andrich S, Beelen R, Brunekreef B et al (2015) Air pollution from road traffic and systemic inflammation in adults: a cross-sectional analysis in the European ESCAPE project. Environ Health Perspect 123(8):785–791CrossRefGoogle Scholar
  23. Lelieveld J, Evans JS, Fnais M, Giannadaki D, Pozzer A (2015) The contribution of outdoor air pollution sources to premature mortality on a global scale. Nature 525:367–371CrossRefGoogle Scholar
  24. McEvoy JW, Nasir K, DeFilippis AP, Lima JAC, Bluemke DA, Hundley WG et al (2015) Relationship of cigarette smoking with in ammation and subclinical vascular disease the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol 35:1002–1010CrossRefGoogle Scholar
  25. Miyata R, Bai N, Vincent R, Sin DD, Van Eeden SF (2013) Statins reduce ambient particulate matter-induced lung inflammation by promoting the clearance of particulate matter <10 μm from lung tissues. Chest 143(2):452–460CrossRefGoogle Scholar
  26. NABEL, the National Air Pollution Monitoring Network Switzerland (2019). Data query NABEL. Website: https://www.bafu.admin.ch/bafu/en/home/topics/air/state/data/data-query-nabel.html. Accessed 5 May 2019
  27. Ostro B, Malig B, Broadwin R, Basu R, Gold EB, Bromberger JT et al (2014) Chronic pm2.5 exposure and inflammation: Determining sensitive subgroups in mid-life women. Environ Res 132:168–175CrossRefGoogle Scholar
  28. Panasevich S, Leander K, Rosenlund M, Ljungman P, Bellander T, de Faire U et al (2009) Associations of long- and short-term air pollution exposure with markers of inflammation and coagulation in a population sample. Occup Environ Med 66:747–753CrossRefGoogle Scholar
  29. Pope CA, Dockery DW (2006) Health effects of fine particulate air pollution: lines that connect. J Air Waste Manage Assoc 56:709–742CrossRefGoogle Scholar
  30. Rioux CL, Tucker KL, Mwamburi M, Gute DM, Cohen SA, Brugge D (2010) Residential traffic exposure, pulse pressure, and C-reactive protein: consistency and contrast among exposure characterization methods. Environ Health Perspect 118:803–811CrossRefGoogle Scholar
  31. Robb CT, Regan KH, Dorward DA, Rossi AG (2016) Key mechanisms governing resolution of lung inflammation. Semin Immunopathol 38:425–448CrossRefGoogle Scholar
  32. Shafran-Nathan R, Yuval LI, Broday DM (2017) Exposure estimation errors to nitrogen oxides on a population scale due to daytime activity away from home. Sci Total Environ 580:1401–1409CrossRefGoogle Scholar
  33. Steinvil A, Kordova-Biezuner L, Shapira I, Berliner S, Rogowski O (2008) Short-term exposure to air pollution and inflammation-sensitive biomarkers. Environ Res 106:51–61CrossRefGoogle Scholar
  34. Tsai D-H, Guessous I, Riediker M, Paccaud F, Gaspoz J-M, Theler J-M et al (2015) Short-term effects of particulate matter on pulse pressure in two general population studies. J Hypertens 33:1144–1152CrossRefGoogle Scholar
  35. Tsai D-H, Amyai N, Marques-Vidal P, Wang JL, Riediker M, Mooser V et al (2012) Effects of particulate matter on inflammatory markers in the general adult population. Part Fibre Toxicol 9:24CrossRefGoogle Scholar
  36. van Eeden SF, Tan WC, Suwa T, Mukae H, Terashima T, Fujii T et al (2001) Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM10). Am J Respir Crit Care Med 164:826–830CrossRefGoogle Scholar
  37. World Health Organization. 2018. Ambient (outdoor) air quality and health. Website: http://www.who.int/news-room/fact-sheets/detail/ambient-(outdoor)-air-quality-and-health. Accessed 5 May 2019

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Dai-Hua Tsai
    • 1
    • 2
  • Michael Riediker
    • 3
    • 4
  • Antoine Berchet
    • 5
    • 6
  • Fred Paccaud
    • 2
  • Gerard Waeber
    • 7
  • Peter Vollenweider
    • 7
  • Murielle Bochud
    • 2
    Email author
  1. 1.Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of ZurichZurichSwitzerland
  2. 2.Institute of Social and Preventive Medicine (IUMSP)Lausanne University Hospital (CHUV)LausanneSwitzerland
  3. 3.Swiss Centre for Occupational and Environmental Health (SCOEH)WinterthurSwitzerland
  4. 4.Institute for Work and Health (IST)University of LausanneEpalingesSwitzerland
  5. 5.Laboratoire des Sciences du Climat et de l’Environnement (LSCE)CEA-CNRS-UVSQ, UMR8212Gif-sur-YvetteFrance
  6. 6.Swiss Federal Laboratories for Materials Science and Technology (EMPA)DübendorfSwitzerland
  7. 7.Department of Medicine, Internal MedicineCHUVLausanneSwitzerland

Personalised recommendations