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Environmental Science and Pollution Research

, Volume 26, Issue 18, pp 18930–18937 | Cite as

Environmental risk assessment of antibiotics in agroecosystems: ecotoxicological effects on aquatic microbial communities and dissemination of antimicrobial resistances and antibiotic biodegradation potential along the soil-water continuum

  • Fabrice Martin-LaurentEmail author
  • Edward Topp
  • Loren Billet
  • Isabelle Batisson
  • Cédric Malandain
  • Pascale Besse-Hoggan
  • Soizic Morin
  • Joan Artigas
  • Chloé Bonnineau
  • Laura Kergoat
  • Marion Devers-Lamrani
  • Stéphane Pesce
Research and Education Highlights

Abstract

Antibiotics have a wide application range in human and veterinary medicines. Being designed for pharmacological stability, most antibiotics are recalcitrant to biodegradation after ingestion and can be persistent in the environment. Antibiotic residues have been detected as contaminants in various environmental compartments where they cause human and environmental threats, notably with respect to the potential emergence and proliferation of antibiotic-resistant bacteria. An important component of managing environmental risk caused by antibiotics is to understand exposure of soil and water resources to their residues. One challenge is to gain knowledge on the fate of antibiotics in the ecosystem along the soil-water continuum, and on the collateral impact of antibiotics on environmental microorganisms responsible for crucially important ecosystem functions. In this context, the ANTIBIOTOX project aims at studying the environmental fate and impact of two antibiotics of the sulfonamide class of antibiotics, sulfamethazine (SMZ), and sulfamethoxazole (SMX).

Keywords

Antibiotics Resistance gene Bacteria Biodegradation 

Notes

Acknowledgements

Fabrice Martin-Laurent is also grateful to the Organization for Economic Co-operation and Development (OECD) for support of a work transfer to E. Topp’s laboratory within the framework of the Co-Operative Research Program within the “Biological Resource Management for Sustainable Agricultural Systems” of the OECD (contract number JA00073530).

Funding information

The authors would like to thank the ANR (Agence Nationale de la Recherche) for funding the ANTIBIOTOX project (contract no ANR-17-CE34-0003).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Fabrice Martin-Laurent
    • 1
    Email author
  • Edward Topp
    • 2
  • Loren Billet
    • 1
  • Isabelle Batisson
    • 3
  • Cédric Malandain
    • 4
  • Pascale Besse-Hoggan
    • 5
  • Soizic Morin
    • 6
  • Joan Artigas
    • 3
  • Chloé Bonnineau
    • 7
  • Laura Kergoat
    • 7
  • Marion Devers-Lamrani
    • 1
  • Stéphane Pesce
    • 7
  1. 1.AgroSup Dijon, INRA, Univ. BourgogneUniv. Bourgogne Franche-ComtéDijonFrance
  2. 2.Agriculture and Agri-Food CanadaUniversity of Western OntarioLondonCanada
  3. 3.CNRS, Laboratoire Microorganismes: Génome et EnvironnementUniversité Clermont AuvergneClermont–FerrandFrance
  4. 4.ENOVEOLyonFrance
  5. 5.CNRS, Sigma Clermont, Institut de Chimie de Clermont-FerrandUniversité Clermont AuvergneClermont–FerrandFrance
  6. 6.Irstea, UR EABXCestasFrance
  7. 7.Irstea, UR RiverLyLyon-VilleurbanneFrance

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