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Environmental Science and Pollution Research

, Volume 26, Issue 18, pp 18247–18255 | Cite as

Association of urinary acrylamide concentration with lifestyle and demographic factors in a population of South Korean children and adolescents

  • Soo Yeon Choi
  • Ahra Ko
  • Hui-Seung KangEmail author
  • Myung-Sil Hwang
  • Hee-Seok LeeEmail author
Research Article
  • 52 Downloads

Abstract

Acrylamide (AA) has been identified as probably carcinogenic to humans and thus represents a potential public health threat. This study aimed to determine the urinary concentrations of AA and N-acetyl-S-(2-carbamoylethyl)-l-cysteine (AAMA) in a nationally representative sample (n = 1025) of children and adolescents (age range 3–18 years) in South Korea. The AA and AAMA detection rates and geometric mean concentrations were 97%, 19.1 ng/mL, and 98.7%, 26.4 ng/mL, respectively. Although urinary AA levels did not vary widely by age (17.2 ng/mL at 3–6 years, 19.9 ng/mL at 7–18 years), the urinary concentration of AAMA increased with age (18.3 ng/mL at 3–6 years, 30.4 ng/mL at 7–18 years). A multiple linear regression analysis revealed that the urinary levels of AA and AAMA varied significantly by sex, with the adjusted proportional changes indicating rates of 1.47- to 1.48-fold higher at 3–6 years and 1.36- to 1.68-fold higher at 7–18 years among males relative to females. Furthermore, the urinary levels of AA and AAMA correlated with the consumption of certain foods (doughnuts, hotdogs, popcorn, and nachos) among male subjects aged 7–18 years. The urinary concentrations of AA and AAMA increased significantly with the smoking status and passive smoking exposure, with adjusted proportional changes of 1.51 to 1.71-fold higher among smokers relative to non-smokers in the age range of 7–18 years. Exposure to smoking for > 30 min led to adjusted proportional increases in AA and AAMA of 1.51 and 1.77 times in the non-smoking group aged 3–6 years and a 1.52-fold increase in AAMA in the non-smoking group aged 7–18 years. In conclusion, the urinary levels of AA and AAMA were found to associate with age, sex, smoking, and food consumption in a population of Korean children and adolescents.

Keywords

Acrylamide N-acetyl-S-(2-carbamoylethyl)-cysteine Urine Demographic Smoking Food consumption 

Notes

Funding information

This study was supported by a grant (no. 11161MFDS723) from the Ministry of Food and Drug Safety in 2011.

Compliance with ethical standards

This study was approved by the Asan Medical Center (Seoul, Korea) Human Research Ethics Committee. All participants provided written informed consent in accordance with the Helsinki Declaration prior to data collection.

References

  1. Alves RC, Soares C, Casal S, Fernandes JO, Oliveira MBP (2010) Acrylamide in espresso coffee: influence of species, roast degree and brew length. Food Chem 119(3):929–934CrossRefGoogle Scholar
  2. Bassett J (2000) The Asia-Pacific perspective: redefining obesity and its treatment health communications Australia. WHO, GenevaGoogle Scholar
  3. Bilau M, Matthys C, Vinkx C, Henauw SD (2003) Probabilistic exposure assessment for acrylamide in Flemish adolescents. Toxicol Lett 21:60CrossRefGoogle Scholar
  4. Bjellaas T, Stølen LH, Haugen M, Paulsen JE, Alexander J, Lundanes E, Becher G (2007) Urinary acrylamide metabolites as biomarkers for short-term dietary exposure to acrylamide. Food Chem Toxicol 45(6):1020–1026CrossRefGoogle Scholar
  5. Boettcher MI, Schettgen T, Kütting B, Pischetsrieder M, Angerer J (2005) Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population. Mutat Res-Gen Tox En 580:167–176CrossRefGoogle Scholar
  6. Boon PE, Mul D, Voet A, Donkersgoed H, Brette GM, Klaveren JD (2005) Calculations of dietary exposure to acrylamide. Mutat Res-Gen Tox En 580:143–155CrossRefGoogle Scholar
  7. Brantsaeter AL, Haugen M, de Mul A, Bjellaas T, Becher G, Van Klaveren J (2008) Exploration of difference methods to assess dietary acrylamide exposure in pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa). Food Chem Toxicol 46:2808–2814CrossRefGoogle Scholar
  8. Burek JD, Albee RR, Beyer JE, Bell TJ, Carreon RM, Morden DC, Wade CE, Hermann EA, Gorzinski SJ (1980) Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol 4:157–182Google Scholar
  9. Calafat AM, Ye X, Wong LY, Bishop AM (2010) Needham AL urinary concentrations of four parabens in the U.S. population: NHANES 2005–2006. Environ Health Persp 118:679–685CrossRefGoogle Scholar
  10. Catalgol B, Ozhan G, Alpertunga B (2009) Acrylamide-induced oxidative stress in human erythrocytes. Hum Exp Toxicol 28:611–617CrossRefGoogle Scholar
  11. DeWoskin RS, Sweeney LM, Teeguarden JG, Sams R, Vandenberg J (2013) Comparison of PBTK model and biomarker based estimates of the internal dosimetry of acrylamide. Food Chem Toxicol 58:506–521CrossRefGoogle Scholar
  12. Dybing E, Farmer PB, Andersen M, Fennell TR, Lalljie SP, Muller DJ, Olin S, Petersen BJ, Schlatter J, Scholz G, Scimeca JA, Slimani N, Tornqvist M, Tuijtelaars S, Verger P (2005) Human exposure and internal dose assessments of acrylamide in food. Food Chem Toxicol 43:365–410CrossRefGoogle Scholar
  13. Dybing E, Sanner T (2003) Risk assessment of acrylamide in foods. Toxicol Sci 75(1):7–15CrossRefGoogle Scholar
  14. FAO/WHO (2002) Health implications of acrylamide in food–report of a Joint FAO/WHO consultation, GenevaGoogle Scholar
  15. Friedman MA, Dulak LH, Stedham MA (1995) A lifetime oncogenicity study in rats with acrylamide. J Soc Toxicol 27:95–105CrossRefGoogle Scholar
  16. Fuhr U, Boettcher MI, Kinzig-Schippers M, Weyer A, Jetter A, Lazar A, Harlfinger S, Klaassen T, Berkessel A, Angerer J, Sörgel F, Schömig E (2006) Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity. Cancer Epidem Biomar 15(2):266–271CrossRefGoogle Scholar
  17. Granby K, Fagt S (2004) Analysis of acrylamide in coffee and dietary exposure to acrylamide from coffee. Anal Chim Acta 520:177–182CrossRefGoogle Scholar
  18. Hartmann EC, Boettcher MI, Schettgen T, Fromme H, Drexler H, Angerer J (2008) Hemoglobin adducts and mercapturic acid excretion of acrylamide and glycidamide in one study population. J Agric Food Chem 56:6061–6068CrossRefGoogle Scholar
  19. Heudorf U, Hartmann E, Angerer J (2009) Acrylamide in children – exposure assessment via urinary acrylamide metabolites as biomarkers. Int J Hyg Environ Health 212:135–141CrossRefGoogle Scholar
  20. Hilbig A, Freidank N, Kersting M, Wilhelm M, Wittsiepe J (2004) Estimation of the dietary intake of acrylamide by German infants, children and adolescents as calculated from dietary records and available data in acrylamide levels in food group. Int J Hyg Environ Health 207:463–471CrossRefGoogle Scholar
  21. Hogervorst JG, Baars BJ, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA (2010) The carcinogenicity of dietary acrylamide intake. Toxicol 40:485–512Google Scholar
  22. International Agency for Research on Cancer (1994) Opinion of the scientific committee on food on new findings regarding the presence of acrylamide in food. Available at: http://europa.eu.int/comm/food/fs/sc/scf/out131_en.pdf
  23. Ji KG, Kang SG, Lee GW, Lee SL, Jo AR, Kwak KH, Kim DH, Kho DH, Lee SW, Kim SM, Kim SK, Hiuang YF, Wu KY, Choi KH (2013) Urinary levels of N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA), an acrylamide metabolite, in Korean children and their association with food consumption. Sci Total Environ 456:17–23CrossRefGoogle Scholar
  24. Kang HS, Ko A, Kwon KE, Kyung MS, Moon GI, Park JH, Lee HS, Suh JH, Lee JM, Hwang MS, Kim KS, Hong JH, Hwang IG (2016) Urinary benzophenone concentrations and their association with demographic factors in a South Korean population. Environ Res 149:1–7CrossRefGoogle Scholar
  25. Konings EJ, Baars KJD, Spanjer MC, Rensen PM, Hiemstra M, Kooij JA, Peters PW (2003) Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. Food Chem Toxicol 41:1569–1579CrossRefGoogle Scholar
  26. Kroes R, Müller D, Lambe J, Löwik MRH, Klaveren J, Kleiner J, Massey R, Mayer S, Urieta I, Verger P, Visconti A (2002) Assessment of intake from the diet. Food Chem Toxicol 40:327–385CrossRefGoogle Scholar
  27. Lee JH, Lee KJ, Ahn R, Kang HS (2014) Urinary concentrations of acrylamide (AA) and N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) and associations with demographic factors in the south Korean population. Int J Hyg Environ Health 217:751–757CrossRefGoogle Scholar
  28. Lee JH, Lee KJ, Kang HS (2016) Estimation of the daily human intake of acrylamide (AA) based on urinary N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) and the contribution of dietary habits in South Korean adults. J Environ Health Sci 42(4):235–245Google Scholar
  29. Lee S, Yoo M, Koo M, Kim HJ, Kim M, Park SK, Shin D (2013) In-house–validated liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for survey of acrylamide in various processed foods from Korean market. Food Sci Nutr 1(5):402–407CrossRefGoogle Scholar
  30. Lin CY, Lee HL, Chen YC, Lien GW, Lin LY, Wen LL, Liao CC, Chien KL, Sung FC, Chen PC, Su TC (2013) Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. J Hazard Mater 261:372–377CrossRefGoogle Scholar
  31. Matthys C, Bilau M, Govaert Y, Moons E, Henauw DS, Willems JL (2005) Risk assessment of dietary acrylamide intake in Flemish adolescents. Food Chem Toxicol 43:271–278CrossRefGoogle Scholar
  32. Mottram DS, Wedzicha BL, Dodson AT (2002) Acrylamide is formed in the Maillard reaction. Nature 419:448–449CrossRefGoogle Scholar
  33. Naruszewicz M, Downar DZ, Kosmider A, Nowicka G, Wojciechowska MK, Vikstrom AS, Tornqvist M (2009) Chronic intake of potato chips in humans increases the production of reactive oxygen radicals by leukocytes and increases plasma C-reactive protein: a pilot study. Am J Clin Nutr 89:773–777CrossRefGoogle Scholar
  34. Park JY, Kim CT, Kim HY; Keum EH, Lee MS, Chung SY, Sho YS, Lee JO, Oh SS (2004) Acrylamide monitoring of domestic food products. Korean J Food Sci Technol36(6): 872–878Google Scholar
  35. Parzefall W (2008) Minireview on the toxicity of dietary acrylamide. Food Chem Toxicol 46:1360–1364CrossRefGoogle Scholar
  36. Pedreschi F, Kaack K, Granby K (2004) Reduction of acrylamide formation in potato slices during frying. Food Chem Toxicol 37(6):679–685Google Scholar
  37. Riboldi BP, Vinhas ÁM, Moreira JD (2014) Risks of dietary acrylamide exposure: a systematic review. Food Chem 157:310–322CrossRefGoogle Scholar
  38. Smith CJ, Perfetti TA, Rumple MA, Rodgman A, Doolittle DJ (2000) IARC group 2A carcinogens reported in cigarette mainstream smoke. Food Chem Toxicol 38:371–383CrossRefGoogle Scholar
  39. Smith, KW, Braun JM, Williams PL, Ehrlich S, Correia KF, Calafat AM, Ye X, Ford J, Keller M, Meeker JD, Hauser R (2012) Predictors and variability of urinary paraben concentrations in men and women, including before and during pregnancy. Environ Health Perspect 120(11):1538–1543CrossRefGoogle Scholar
  40. Svensson K, Abramsson L, Becker W, Glynn A, Hellenas KE, Lind Y, Rosen J (2003) Dietary intake of acrylamide in Sweden. Food Chem Toxicol 41:1581–1586CrossRefGoogle Scholar
  41. Swedish National Food Administration (2002) Acrylamide is formed during the preparation of food and occurs in many foodstuffs. Available at: http://www.slv.se
  42. Sweeney LM, Kirman RC, Gargas ML, Carson ML, Tardiff RG (2010) Development of a physiologically-based toxicokinetic model of acrylamide and glycidamide in rats and humans. Food Chem Toxicol 48:668–685CrossRefGoogle Scholar
  43. Urban M, Kavvadias D, Riedel K, Scherer G, Tricker AR (2006) Urinary mercapturic acids and a hemoglobin adduct for the dosimetry of acrylamide exposure in smokers and nonsmokers. Inhal Toxicol 18:831–839CrossRefGoogle Scholar
  44. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell B 39:44–84CrossRefGoogle Scholar
  45. Ye X, Wong LY, Bishop AM, Calafat AM (2011) Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections. Environ Health Persp 119:983–988CrossRefGoogle Scholar
  46. Yousef MI, Demerdash FME (2006) Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicol 219:133–141CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Pesticide and Veterinary Drugs Residue DivisionNational Institute of Food and Drug Safety EvaluationCheongjuRepublic of Korea
  2. 2.Food Safety Risk Assessment DivisionNational Institute of Food and Drug Safety EvaluationCheongjuRepublic of Korea

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