Does water temperature influence the distribution and elimination of perfluorinated substances in rainbow trout (Oncorhynchus mykiss)?
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Perfluorinated and polyfluorinated substances (PFASs) are widely found in freshwater ecosystems because of their resistance to degradation and their ability to accumulate in aquatic organisms. While water temperature controls many physiological processes in fish, knowledge of the effects of this factor on PFAS toxicokinetic is still limited. This study presents experimental results of internal distribution and elimination rates of two perfluorinated acid compounds, namely perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) in adult rainbow trout (Oncorhynchus mykiss) exposed to three temperatures. Dietary exposure experiments were conducted at 7 °C, 11 °C, and 19 °C and liver, blood, muscle, brain, and kidney were sampled for analysis. PFOS concentrations were comparable to or exceeded those of PFHxS, while PFHxS was eliminated faster than PFOS, whatever the temperature. Internal distribution changed significantly for both substances when fish were exposed to a range of temperatures from 7 to 19 °C. Indeed, PFOS and PFHxS relative distribution increased in blood, liver, and brain while they decreased in muscle when the water temperature rose. The water temperature variation affected the elimination half-lives, depending on the substances and organs.
KeywordsPerfluoroalkyl substances Rainbow trout Temperature Elimination rate Internal distribution
We thank Emilien Lasne and Laurent Espinat (INRA Thonon-les-Bains research station), Charline Gesset, Patrick Chevre, and Louis Jacob (Irstea, St-Seurin-sur-l’Isle experimental station) for their kind and active support during the experiments, as well as Ina Goeritz, for providing her experimental data and metadata. We also thank Linda Northrup (English Solutions, Voiron, France) for copyediting the manuscript.
Role of the funding source
The experiments, including the analyses, were funded by the Rhone-Mediterranean and Corsica Water Agency. The Rhone-Alpes Region provided a doctoral fellowship grant for Alice Vidal.
None of the funding sources were involved in the study design, in data processing, or in the decisions related to manuscript writing and submission.
Study design, experimental and analytical work, and data processing were done by the authors, in particular Alice Vidal, with support from technical staff.
Compliance with ethical standards
Conflict of interest
The authors declare they have no conflict of interest.
- Ahrens L, Bundschuh M (2014) Fate and effects of poly- and perfluoroalkyl substances in the aquatic environment: a review. Environ Toxicol Chem 33:1921–1929Google Scholar
- Babut M, Labadie P, Simonnet-Laprade C, Munoz G, Roger M-C, Ferrari BJD, Budzinski H, Sivade E (2017) Per- and poly-fluoroalkyl compounds in freshwater fish from the Rhône River: influence of fish size, diet, prey contamination and biotransformation. Sci Tot Environ 605-606:38–47CrossRefGoogle Scholar
- Barron MG, Tarr BD, Hayton WL (1987) Temperature-dependence of cardiac output and regional blood flow in rainbow trout, Salmo gairdneri Richardson. J Fish Biol 31:735–744. https://doi.org/10.1111/j.1095-8649.1987.tb05276.x CrossRefGoogle Scholar
- Curtis LR (1986) Glucuronidation and biliary excretion of phenolphthalein in temperature acclimated steelhead trout (Salmo gairdneri). Comp Biochem Physiol Part C: Comp Pharmacol 76:107–111Google Scholar
- European Union (2006) Directive 2006/122/EC of the European Parliament and of the Council of 12 December 2006 amending for the 30th time Council Directive 76/769/EEC on the approximation of the laws, regulations and administrative provisions of the Member States relating to restrictions on amrketing and use of certain dangerous substances and preparations (perfluorooctane sulfonates). Off. J Eur Union L372:32–34Google Scholar
- Fry FEJ (1971) The effects of environmental factors on the physiology of fishes. In: Hoar WS, Randall DJ (eds) Fish physiology, vol 6. Academic Press, New York, pp 1–98Google Scholar
- Fulton (1902) Rate of growth of seas fishes. Sci Invest Fish Div Scot Rept 20:1035–1039Google Scholar
- Gaillard J, Veyrand B, Thomas M, Dauchy X, Boiteux V, Marchand P, Le Bizec B, Banas D, Feidt C (2017) Tissue uptake, distribution, and elimination of perfluoroalkyl substances in juvenile perch through perfluorooctane sulfonamidoethanol based phosphate diester dietary exposure. Environ Sci Technol. 51:7658–7666. https://doi.org/10.1021/acs.est.6b05598 CrossRefGoogle Scholar
- IPCC (2013) In: Stocker TF, Qin D, Plattner G-K, Tignor M, Allen SK, Boschung J, Nauels A, Xia Y, Bex V, Midgley PM (eds) Climate change 2013: the physical science basisGoogle Scholar
- Jimenez BD, Cirmo CP, McCarthy JF (1987) Effects of feeding and temperature on uptake, elimination and metabolism of benzo(a) pyrene in the bluegill sunfish (Lepomis macrochirus). Environ Sci 10:41–57Google Scholar
- OECD (2002) Hazard assessment of perflurooctane sulphonate (PFOS) and its salts. Organisation for Economic Co-operation and DevelopmentGoogle Scholar
- OECD (2012) Bioaccumulation in fish: aqueous and dietary exposure. (OECD guidelines for testing of chemicals, TG 305.) Organisation for Economic Co-operation and DevelopmentGoogle Scholar
- R Core Development Team (2016) R: a language and environment for statistical computing. R Foundation for Statistical. Computing, Vienna, AustriaGoogle Scholar
- Raleigh RF, Hickman T, Solomon RC Nelson PC (1984) Habitat Suitability Index Models: Rainbow trout. FWS/OBSGoogle Scholar
- Shi Y, Vestergren R, Nost TH, Zhou Z, Cai Y (2018) Probing the differential tissue distribution and bioaccumulation behavior of per- and polyfluoroalkyl substances of varying chain-lengths, isomeric structures and functional groups in crucian carp. Environ Sci Technol. 52:4592–4600. https://doi.org/10.1021/acs.est.7b06128 CrossRefGoogle Scholar
- Wang Z, Cousins IT, Scheringer M, Hungerbuehler K (2015) Hazard assessment of fluorinated alternatives to long-chain perfluoroalkyl acids (PFAAs) and their precursors: status quo, ongoing challenges and possible solutions. Environ Int 75:172–179. https://doi.org/10.1016/j.envint.2014.11.013 CrossRefGoogle Scholar
- Williams JE, Isaak DJ, Imhof J, Hendrickson DA, McMillan JR (2015) Cold-water fishes and climate change in North America. Ref Module Earth Syst Environ Sci. https://doi.org/10.1016/B978-0-12-409548-9.09505-1
- Zhong W, Zhang L, Cui Y, Chen M, Zhu L (2019) Probing mechanisms for bioaccumulation of perfluoroalkyl acids in carp (Cyprinus carpio): impacts of protein binding affinities and elimination pathways. Sci Tot Environ. 647:992–999. https://doi.org/10.1016/j.scitotenv.2018.08.099 CrossRefGoogle Scholar