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Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) microspheres for controlled release of buprofezin

  • Chan ZhangEmail author
  • Ruzhu Jia
  • Yuefeng Dong
  • Liangqi Zhao
Research Article
  • 35 Downloads

Abstract

Extensive application of pesticides has caused a lot of environmental pollution and health problems, prompting the development of highly efficient and lowly toxic pesticide formulations. Here, buprofezin (BPF)-loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(HB-HH)) microspheres were prepared by O/W emulsion/solvent evaporation method. Under optimal conditions (P(HB-HH) 7.07% (w/v) and PVA 1.84% (w/v)), the spherical and monodispersed microspheres were obtained. The average particle size, pesticide loading (PL), and encapsulation efficiency (EE) of the optimized microspheres were 1.2 μm, 15.68%, and 78%, respectively. Release of 80% BPF from the microspheres in pH 5 (192 h) was faster than that in pH 7 (228 h) and 8 (204 h). Moreover, kinetic analysis indicated that BPF release behaved in a non-Fickian diffusion manner (0.43 < n < 0.85) and the release mechanism was the combined effects of pesticide diffusion and hydrolysis of polymer. The bioassay and toxicity results showed that encapsulation of BPF could exhibit high efficacy on the target organism and low toxicity to the non-target organism. Therefore, these results demonstrated that BPF-loaded P(HB-HH) microspheres with good stability were prepared successfully, and they could be further explored for constructing other highly efficient and lowly toxic pesticide formulations.

Keywords

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Optimization Controlled release Buprofezin 

Notes

Funding information

This work was supported by the Science and Technology Program of Shanxi Province (201803D221002-1) and the Natural Science Foundation for Young Scientists of Shanxi Province, China (2013021011-7).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

References

  1. Chauhan N, Dilbaghi N, Gopal M, Kumar R, Kim KH, Kumar S (2017) Development of chitosan nanocapsules for the controlled release of hexaconazole. Int J Biol Macromol 97:616–624CrossRefGoogle Scholar
  2. Dash TK, Konkimalla VB (2012) Poly-є-caprolactone based formulations for drug delivery and tissue engineering: a review. J Control Release 158:15–33CrossRefGoogle Scholar
  3. Feng JG, Yang GT, Zhang SW, Liu Q, Jafari SM, McClements DJ (2018) Fabrication and characterization of β-cypermethrin-loaded PLA microcapsules prepared by emulsion-solvent evaporation: loading and release properties. Environ Sci Pollut Res 25:13525–13535CrossRefGoogle Scholar
  4. García-González CA, Jin M, Gerth J, Alvarez-Lorenzo C, Smirnova I (2015) Polysaccharide-based aerogel microspheres for oral drug delivery. Carbohydr Polym 117:797–806CrossRefGoogle Scholar
  5. Gerling D, Sinai P (1994) Buprofezin effects on two parasitoid species of whitefly (Homoptera: Aleyrodidae). J Econ Entomol 87:842–846CrossRefGoogle Scholar
  6. Grillo R, Melo de NFS, Lima de R, Loureno RW, Rosa AH, Fraceto LF (2010) Characterization of atrazine-loaded biodegradable poly (hydroxybutyrate-co-hydroxyvalerate) microspheres. J Polym Environ 18:26–32CrossRefGoogle Scholar
  7. Grillo R, Santo Pereira ADE, Melo de NFS, Porto RM, Feitosa LO, Tonello PS, Filho NLD, Rosa AH, Lima R, Fraceto LF (2011) Controlled release system for ametryn using polymer microspheres: preparation, characterization and release kinetics in water. J Hazard Mater 186:1645–1651CrossRefGoogle Scholar
  8. Hernández AF, Parrón T, Tsatsakis AM, Requena M, Alarcón R, López-Guarnido O (2013) Toxic effects of pesticide mixtures at a molecular level: their relevance to human health. Toxicology 307:136–145CrossRefGoogle Scholar
  9. Hoi PV, Mol APJ, Oosterveer P, Brink PJVD, Huong PTM (2016) Pesticide use in Vietnamese vegetable production: a 10-year study. Int J Agric Sustain 14:325–338CrossRefGoogle Scholar
  10. Ji X, Ku T, Zhu N, Ning X, Wei W, Li GK, Sang N (2016) Potential hepatic toxicity of buprofezin at sublethal concentrations: ROS-mediated conversion of energy metabolism. J Hazard Mater 320:176–186CrossRefGoogle Scholar
  11. Ku T, Yan W, Jia W, Yun Y, Zhu N, Li GK, Sang N (2015) Characterization of synergistic embryotoxicity of nickel and buprofezin in zebrafish. Environ Sci Technol 49:4600–4608CrossRefGoogle Scholar
  12. Kumar S, Bhanjana G, Sharma A, Sidhu MC, Dilbaghi N (2014) Synthesis, characterization and on field evaluation of pesticide loaded sodium alginate nanoparticles. Carbohydr Polym 101:1061–1067CrossRefGoogle Scholar
  13. Kumar S, Chauhan N, Gopal M, Kumar R, Dilbaghi N (2015) Development and evaluation of alginate–chitosan nanocapsules for controlled release of acetamiprid. Int J Biol Macromol 81:631–637CrossRefGoogle Scholar
  14. Li M, Rouaud O, Poncelet D (2008) Microencapsulation by solvent evaporation: state of the art for process engineering approaches. Int J Pharm 363:26–39CrossRefGoogle Scholar
  15. Li D, Liu B, Yang F, Wang X, Shen H, Wu D (2016) Preparation of uniform starch microcapsules by premix membrane emulsion for controlled release of avermectin. Carbohydr Polym 136:341–349CrossRefGoogle Scholar
  16. Li Y, Zhou M, Pang Y, Qiu XQ (2017) Lignin-based microsphere: preparation and performance on encapsulating the pesticide avermectin. ACS Sustain Chem Eng 5:3321–3328CrossRefGoogle Scholar
  17. Liu B, Wang Y, Yang F, Wang X, Shen H, Cui H, Wu D (2016) Construction of a controlled-release delivery system for pesticides using biodegradable PLA-based microcapsules. Colloids Surf B: Biointerfaces 144:38–45CrossRefGoogle Scholar
  18. Otto DP, Vosloo HCM, Liebenberg W, Villiers MMD (2008) Development of microporous drug-releasing films cast from artificial nano-sized latexes of poly(styrene-co-methyl methacrylate) or poly(styrene-co-ethylmethacrylate). Eur J Pharm Biopharm 69:1121–1134CrossRefGoogle Scholar
  19. Peppas NA (1984) Release of bioactive agents from swellable polymers: theory and experiments. Recent advances in drug delivery systems. Springer, Boston, MA, pp 279–289CrossRefGoogle Scholar
  20. Rasmussen JJ, Wiberg-Larsen P, Baattrup-Pedersen A, Cedergreen N, McKnight US, Kreuger J, Jacobsen D, Kristensen EA, Friberg N (2015) The legacy of pesticide pollution: an overlooked factor in current risk assessments of freshwater systems. Water Res 84:25–32CrossRefGoogle Scholar
  21. Ritger PL, Peppas NA (1987) A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release 5:37–42CrossRefGoogle Scholar
  22. Shao T, Bai L, Yan B, Jin Y, Cheng Y (2017) Modeling the solidification of O/W-emulsion droplet in solvent evaporation technique. Chem Eng Res Des 122:233–242CrossRefGoogle Scholar
  23. Shi X, Wang Y, Varshney RR, Ren L, Gong Y, Wang DA (2010) Microsphere-based drug releasing scaffolds for inducing osteogenesis of human mesenchymal stem cells in vitro. Eur J Pharm Sci 39:59–67CrossRefGoogle Scholar
  24. Zhang C, Dong YF, Wang HB, Zhao LQ (2007) Studies on synthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by a Sinorhizobium fredii strain. Microbiology 34:1077–1081Google Scholar
  25. Zhang WJ, Jiang FB, Ou JF (2011) Global pesticide consumption and pollution: with China as a focus. Proceedings of the International Academy of Ecology and Environmental Sciences 1:125Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Chan Zhang
    • 1
    Email author
  • Ruzhu Jia
    • 1
  • Yuefeng Dong
    • 2
  • Liangqi Zhao
    • 3
  1. 1.School of Environment and SafetyTaiyuan University of Science and TechnologyTaiyuanChina
  2. 2.Shanxi Institute of Medicine and Life ScienceTaiyuanChina
  3. 3.Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuanChina

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